产品中心

Product center

BGP-15 98%

(Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide

源叶(MedMol)
S80878
66611-37-8
C14H22N4O2
278.35008
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S80878-1mg 98% ¥106.00元 10 - - -
源叶(MedMol) S80878-5mg 98% ¥315.00元 6 - - -
源叶(MedMol) S80878-10mg 98% ¥590.00元 6 - - -
源叶(MedMol) S80878-25mg 98% ¥1290.00元 6 - - -
源叶(MedMol) S80878-50mg 98% ¥1930.00元 5 - - -
源叶(MedMol) S80878-100mg 98% ¥2650.00元 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

BGP-15 is a PARP inhibitor, with an IC50 and a Ki of 120 and 57 μM, respectively.
产品描述: BGP-15 is a PARP inhibitor, with an IC50 and a Ki of 120 and 57 μM, respectively.
靶点: PARP:120 μM (IC50);PARP
体内研究:
BGP-15 (15 mg/kg, p.o.) does not improve skeletal muscle pathology in older mdx mice. In a rat model, 10 days of BGP-15 treatment greatly improves diaphragm muscle fiber function (by about 100%), although it does not reverse diaphragm atrophy. The treatment also provides protection from myosin PTMs associated with HSP72 induction and PARP-1 inhibition, resulting in improvement of mitochondrial function and content. BGP-15 (15 mg/kg per day in saline) treatment has no effect in Ntg mice or an independent cohort of normal adult wild-type mice based on morphology, cardiac function and ECG parameters. Treatment with BGP-15 attenuates the increase in atrial size and lung weight. BGP-15 treatment is able to prevent or reduce episodes of arrhythmia. BGP-15 treatment is associated with a reduced PR interval in the HF+AF model. BGP-15 (10 and 30 mg/kg) increases insulin sensitivity by 50% and 70%, respectively, in cholesterol-fed but not in normal rabbits. After 5 days of treatment with BGP-15, the glucose infusion rate is increased in a dose-dependent manner in genetically insulin-resistant GK rats. The most effective dose is 20 mg/kg, which shows a 71% increase in insulin sensitivity compared to control group
参考文献:
1. Kennedy TL, et al. BGP-15 Improves Aspects of the Dystrophic Pathology in mdx and dko Mice with Differing Efficacies in Heart and Skeletal Muscle. Am J Pathol. 2016 Dec;186(12):3246-3260 2. Salah H, et al. The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction. Sci Transl Med. 2016 Aug 3;8(350):350ra10 3. Sapra G, et al. The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice. Nat Commun. 2014 Dec 9;5:5705 4. Literati-Nagy B, et al. Improvement of insulin sensitivity by a novel drug candidate, BGP-15, in different animal studies. Metab Syndr Relat Disord. 2014 Mar;12(2):125-31 5. Sarszegi Z, et al. BGP-15, a PARP-inhibitor, prevents imatinib-induced cardiotoxicity by activating Akt and suppressing JNK and p38 MAP kinases. Mol Cell Biochem. 2012 Jun;365(1-2):129-37 6. Szabados E, et al. BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase. Biochem Pharmacol. 2000 Apr 15;59(8):937-45.
溶解性: H2O  :  100  mg/mL  (284.68  mM;  Need  ultrasonic)    DMSO  :  11.33  mg/mL  (32.25  mM;  Need  ultrasonic  and  warming)
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 3.593 ml 17.963 ml 35.926 ml
5 mM 0.719 ml 3.593 ml 7.185 ml
10 mM 0.359 ml 1.796 ml 3.593 ml
50 mM 0.072 ml 0.359 ml 0.719 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

如何获取质检证书(COA)?
请输入货号和一个与之匹配的批号。
例如:
批号:C10000001 货号:A800001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

=
×
×

相关产品