• 产品描述： Halobetasol Propionate is the propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses across cell membranes to interact with cytoplasmic corticosteroid receptors located in both the dermal and intradermal cells, thereby activating gene expression of anti-inflammatory proteins mediated via corticosteroid receptor response element. Specifically, this agent induces phospholipase A2 inhibitory proteins, which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes. As a result, halobetasol reduces edema, erythema, and pruritus through its cutaneous effects on vascular dilation and permeability.

• 靶点： Phospholipase

• 参考文献：
  1.Mohandas S, et al. Indian J Dermatol Venereol Leprol, 2009, 75(2), 186-187.

• 溶解性： H2O:<1  mg/mL    Ethanol:36  mg/mL  (74.2  mM)    DMSO:90  mg/mL  (185.6  mM)

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.062 ml	10.31 ml	20.62 ml
  5 mM	0.412 ml	2.062 ml	4.124 ml
  10 mM	0.206 ml	1.031 ml	2.062 ml
  50 mM	0.041 ml	0.206 ml	0.412 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *