(Z)-4-Hydroxytamoxifen

    
99%

(Z)-4-Hydroxytamoxifen

源叶(MedMol)
S80892 一键复制产品信息
68047-06-3
C26H29NO2
387.51
MFCD00278780
(Z)-4-羟基三苯氧胺;反式-4-羟基三苯氧胺
货号 规格 价格 上海 北京 武汉 南京 购买数量
S80892-5mg 99% ¥280.00 9 - - -
S80892-10mg 99% ¥520.00 4 - - -
S80892-25mg 99% ¥1040.00 4 - - -
S80892-50mg 99% ¥2000.00 4 - - -
产品介绍 参考文献(1篇) 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is an orally active, selective estrogen receptor modulator (SERM). 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) induces CRISPR/Cas9 systems based on ER mediated nucleus translocation

产品描述: 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is an orally active, selective estrogen receptor modulator (SERM). 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) induces CRISPR/Cas9 systems based on ER mediated nucleus translocation
靶点: Estrogen receptor:3.3 nM (IC50);CRISPR/Cas9 ;EstrogenReceptor/ERR;Estrogen/progestogenReceptor
体内研究: 4-Hydroxytamoxifen (0.2, 1 and 5 μg/day, p.o.) causes a dose-related decrease in uterine wet weight of immature rats. 4-Hydroxytamoxifen (6 μg/0.1 mL sesame oil/day, s.c.) effectively attenuates methamphetamine-induced nigrostriatal dopamine depletions in bothsexes of intact and gonadectomized C57BL/6 J mice. 4-Hydroxytamoxifen does not alter the dopamine content levels in the striatum
参考文献: 1. Jordan VC, et al. A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. J Endocrinol. 1977 Nov;75(2):305-16. 2. Davis KM, et al. Small molecule-triggered Cas9 protein with improved genome-editing specificity. Nat Chem Biol. 2015 May;11(5):316-8. 3. Kuo YM, et al. 4-Hydroxytamoxifen attenuates methamphetamine-induced nigrostriatal dopaminergic toxicity in intact and gonadetomized mice. J Neurochem. 2003 Dec;87(6):1436-43. 4. Zhang J, et al. Drug Inducible CRISPR/Cas Systems. Comput Struct Biotechnol J. 2019;17:1171-1177.
溶解性: DMSO  :  50  mg/mL  (129.03  mM;  ultrasonic  and  warming  and  heat  to  60°C)    Ethanol  :  20  mg/mL  (51.61  mM;  Need  ultrasonic)
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.581 ml 12.903 ml 25.806 ml
5 mM 0.516 ml 2.581 ml 5.161 ml
10 mM 0.258 ml 1.29 ml 2.581 ml
50 mM 0.052 ml 0.258 ml 0.516 ml
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摩尔浓度计算器

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