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• 产品描述： CYC-116 is a potent aurora A and aurora B inhibitor with Kis of 8 and 9 nM, respectively.

• 靶点： Aurora A:8 nM (Ki);Aurora B:9.2 nM (Ki)

• 体内研究：
  Oral administration of CYC-116 at dose levels of 75 and 100 mg/kg q.d. causes tumor growth delays of 2.3 and 5.8 days, which translates into specific growth delays of 0.32 and 0.81, respectively. The mean relative tumor volumes of mice receiving CYC-116 at both dose levels are less than those of vehicle-treated mice for the duration of the study period. At 100 mg/kg po q.d., the reduction in growth is statistically significant on days 6 and 9

• 参考文献：
  1. Wang S, et al. Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors. J Med Chem. 2010 Jun 10;53(11):4367-78.

• 溶解性： DMSO  :  15  mg/mL  (40.71  mM;  Need  ultrasonic)    H2O  :  <  0.1  mg/mL  (insoluble)

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.714 ml	13.57 ml	27.14 ml
  5 mM	0.543 ml	2.714 ml	5.428 ml
  10 mM	0.271 ml	1.357 ml	2.714 ml
  50 mM	0.054 ml	0.271 ml	0.543 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 1. [IF=5.988] Qun Wang et al."Study on the liver Drug’s dominant metabolic enzymes for six effective components of the Huang qi Liuyi decoction."Frontiers in Pharmacology.2023; 14: 1175896

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *