源叶(MedMol)
S80952
一键复制产品信息
79455-30-4
C15H16N4O2
284.31314
烟拉文;N,N'-亚丙基双烟酰胺;尼卡拉温;n,n'-propylenedinicotinamide;NICARAVEN;1,2-bis(nicotinamido)propane;AVS;N,N'-(1-Methylethylene)bis(pyridine-3-carboxamide);N,N'-(1-Methylethylene)bisnicotinamide;N,N'-Propylenebi
Nicaraven 99.80%
| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80952-5mg买3赠1 |
99.80% | ￥100.00 |
10 | - | - | - | - |
|
S80952-10mg买3赠1 |
99.80% | ￥148.00 |
>10 | - | - | - | - |
|
S80952-50mg |
99.80% | ￥320.00 |
7 | - | - | - | - |
|
S80952-100mg |
99.80% | ￥580.00 |
5 | - | - | - | - |
|
S80952-200mg |
≥99% | ￥1080.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | Nicaraven is a novel chemically synthesized hydroxyl radical-specific scavenger. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 体内研究： | Nicaraven inhibits lipid peroxidation in the liver, improves hepatic and systemic hemodynamics and energy metabolism, and suppresses liver enzyme release, endothelin-1 elevation in hepatic venous blood, histologic damage, and neutrophil infiltration into the liver. Nicaraven increases the number of c-kit(+) stem/progenitor cells in bone marrow and peripheral blood, with a recovery rate around 60-90% of age-matched non-irradiated healthy mice. The potency of colony forming from hematopoietic stem/progenitor cells as indicator of function is completely protected with nicaraven treatment. Administration of nicaraven significantly increases the number, improves the colony-forming capacity, and decreases the DNA damage of hematopoietic stem/progenitor cells. The urinary levels of 8-oxo-2′-deoxyguanosine, a marker of DNA oxidation, are significantly lower in mice that are given nicaraven compared with those that receive a placebo. The administration of nicaraven significantly decreases the levels of the inflammatory cytokines IL-6 and TNF-α in the plasma of mice | ||||||||||||||||||||
| 参考文献： | 1. Komiya T, et al. A novel free radical scavenger, nicaraven, inhibits human platelet aggregation in vitro. Clin Neuropharmacol. 1999 Jan-Feb;22(1):11-4. 2. Yokota R, et al. A novel hydroxyl radical scavenger, nicaraven, protects the liver from warm ischemia and reperfusion injury. Surgery. 2000 Jun;127(6):661-9. 3. Ali H, et al. The potential benefits of nicaraven to protect against radiation-induced injury in hematopoietic stem/progenitor cells with relative low dose exposures. 4. Nicaraven attenuates radiation-induced injury in hematopoietic stem/progenitor cells in mice. PLoS One. 2013;8(3):e60023. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 100 mg/mL (351.73 mM) H2O : ≥ 50 mg/mL (175.86 mM) | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
参考文献
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