| 产品描述： | Alfuzosin hydrochloride is an α1 adrenergic receptor antagonist. It applies to treat benign prostatic hyperplasia (BPH). |
| 靶点： |
Adrenergic Receptor;AdrenergicReceptor |
| 体内研究： |
Alfuzosin (300 nM) significantly prolongs action potential duration (APD)(60) in rabbit Purkinje fibers and QT in isolated rabbit hearts. Alfuzosin enhances the number and amplitude of erections induced by apomorphine in spontaneous hypertensive rats (SHR). Alfuzosin behaves as an alpha-adrenergic antagonist blocking the contractions induced by exogenous noradrenaline without altering spikes in both portions of the vas deferens. Alfuzosin (0.03-0.3 mg kg-1, i.v.) markedly inhibits pressor responses produced by the alpha 1-selective agonist, Cirazoline but inhibits only slightly responses to the alpha 2-selective agonist, UK 14,304, in the pithed rat. Alfuzosin (1 mg kg-1, i.v.) has minimal effects against responses mediated by stimulation of prejunctional alpha 2-receptors (UK 14,304-induced inhibition of sympathetic tachycardia). Alfuzosin (0.001-1 mg kg-1, i.v.) and Prazosin (0.001-0.3 mg kg-1, i.v.) produces dose-related inhibition of the increases in urethral pressure caused by stimulation of sympathetic hypogastric nerves in the anaesthetized cat. |
| 参考文献： |
1.Palea S, et al. BJU Int,2003, 91(9), 873-877. 2.Lacerda AE, et al. J Pharmacol Exp Ther,2008, 324(2), 427-433. 3.Tambaro S, et al. J Pharmacol Exp Ther,2005, 312(2), 710-717. 4.Mayoux E, et al. Eur Urol,2004, 45(1), 110-116. 5.Lefèvre-Borg F, et al. Br J Pharmacol. 1993 Aug;109(4):1282-9. |
| 溶解性： |
DMSO:10.7 mg/mL (25 mM) H2O:10.7 mg/mL (25 mM) |
| 保存条件： |
RT |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.348 ml |
11.74 ml |
23.479 ml |
| 5 mM |
0.47 ml |
2.348 ml |
4.696 ml |
| 10 mM |
0.235 ml |
1.174 ml |
2.348 ml |
| 50 mM |
0.047 ml |
0.235 ml |
0.47 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京