货号	规格	价格	上海	北京	武汉	南京
S81031-5mg	99.0%	￥60.00 S81031-5mg ￥60.00 现货	9 9	-	-	-
S81031-10mg	99.0%	￥70.00 S81031-10mg ￥70.00 现货	10 10	-	-	-
S81031-50mg	99.0%	￥110.00 S81031-50mg ￥110.00 现货	2 2	-	-	-
S81031-100mg	99.0%	￥190.00 S81031-100mg ￥190.00 现货	5 5	-	-	-
S81031-200mg	99.0%	￥350.00 S81031-200mg ￥350.00 现货	2 2	-	-	-
S81031-1g	≥99%	￥990.00 S81031-1g ￥990.00 2-3天	0 货期：2-3天	-	-	-

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产品介绍

Tideglusib (NP031112) is an irreversible GSK-3 inhibitor with IC50s of 5 nM and 60 nM for GSK-3βWT (1 h preincubation) and GSK-3βC199A (1 h preincubation), respectively.

产品描述：

Tideglusib (NP031112) is an irreversible GSK-3 inhibitor with IC50s of 5 nM and 60 nM for GSK-3βWT (1 h preincubation) and GSK-3βC199A (1 h preincubation), respectively.

靶点：

GSK-3β(WT):5 nM (IC50);GSK-3β(C199A):60 nM (IC50);GSK-3

体内研究：

Injection of Tideglusib (NP031112) (50 mg/kg) into the rat hippocampus dramatically reduces kainic acid-induced inflammation, as measured by edema formation using T2-weighted magnetic resonance imaging and glial activation and has a neuroprotective effect in the damaged areas of the hippocampus

参考文献：

1. Domínguez JM, et al. Evidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusib. J Biol Chem, 2012, 287(2), 893-90 2. Luna-Medina R, et al. NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders. J Neurosci, 2007, 27(21), 5766-5776.

溶解性：

DMSO : 33.33 mg/mL (99.67 mM; Need ultrasonic) H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.991 ml	14.953 ml	29.905 ml
5 mM	0.598 ml	2.991 ml	5.981 ml
10 mM	0.299 ml	1.495 ml	2.991 ml
50 mM	0.06 ml	0.299 ml	0.598 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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