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• 产品描述： Manidipine, a calcium channel blocker, which is dihydropyridine type. It is utilized

• 靶点： Calcium Channel;CalciumChannel

• 体内研究：
  Manidipine reduces systolic blood pressure with a slight sympathetic reflex increase in heart rate, and increases plasma nitrite/nitrates in perfused rat heart from ischemia-reperfusion damage. Manidipine combined with Simvastatin reduces creatine kinase, lactate dehydrogenase and tumor necrosis factor-alpha, and enhancement of 6-keto-PGF(1alpha) during reperfusion. Manidipine hydrochloride prevents isoproterenol-induced left ventricular hypertrophy and expression of mRNA of ANP, collagen types I and type III, and fibronectin in rats with isoproterenol-induced cardiac hypertrophy. Manidipine HCl increases renal blood flow (RBF) by dilating the afferent arterioles and improves glomerular hypertension by dilating the efferent arterioles in hypertensive rats.

• 参考文献：
  1.Yoshiyama M, et al. Jpn Circ J, 1998, 62(1), 47-52. 2.Rossoni G, et al. Eur J Pharmacol, 2008, 587(1-3), 224-230. 3.Roth M, et al. Proc Natl Acad Sci U S A, 1992, 89(9), 4071-4075. 4.Tojo A, et al. J Cardiovasc Pharmacol, 1992, 20(6), 895-899. 5.Huang S, et al. Am Heart J, 1993, 125(2 Pt 2), 589-597.

• 溶解性： DMSO:113  mg/mL  (185  mM)    H2O:<1  mg/mL    Ethanol:3  mg/mL  (4.91  mM)

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.637 ml	8.187 ml	16.375 ml
  5 mM	0.327 ml	1.637 ml	3.275 ml
  10 mM	0.164 ml	0.819 ml	1.637 ml
  50 mM	0.033 ml	0.164 ml	0.327 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *