品牌	货号	产品规格	价格(RMB)	库存（上海）	北京	武汉	南京
源叶(MedMol)	S81143-2mg	98%	￥408.00元	预计交期：2-3天	-	-	-
源叶(MedMol)	S81143-5mg	98%	￥598.40元	1	-	-	-
源叶(MedMol)	S81143-10mg	98%	￥1020.00元	7	-	-	-
源叶(MedMol)	S81143-25mg	98%	￥2040.00元	6	-	-	-
源叶(MedMol)	S81143-50mg	98%	￥3400.00元	预计交期：2-3天	-	-	-
源叶(MedMol)	S81143-100mg	98%	￥5440.00元	预计交期：2-3天	-	-	-
源叶(MedMol)	S81143-200mg	98%	￥7800.00元	预计交期：2-3天	-	-	-

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产品介绍

SCH772984 is a highly selective and ATP-competitive ERK inhibitor, with IC50s of 4 and 1 nM for ERK1 and ERK2, respectively. SCH772984 has antitumor activity in MAPK inhibitor-naïve and MAPK inhibitor-resistant cells containing BRAF or RAS mutations

产品描述：

靶点：

ERK2：1 nM (IC50)；ERK1：4 nM (IC50);ERK; MEK

体内研究：

SCH772984 (12.5-50 mg/kg; i.p.; twice daily for 14 days) leads to 98% tumor regression. Dose-dependent antitumor activity is also observed in the KRAS-mutant pancreatic MiaPaCa model, with 36% regression at 50 mg/kg twice daily. Importantly, tumor regression is accompanied by robust inhibition of ERK phosphorylation in tumor tissue. SCH772984 is well tolerated on this schedule as measured by morbidity, lethality, or body weight loss。

参考文献：

1. Morris EJ, et al. Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. Cancer Discov. 2013 Jul;3(7):742-50.

溶解性：

DMSO : 48 mg/mL (81.68 mM; Need ultrasonic)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.702 ml	8.508 ml	17.016 ml
5 mM	0.34 ml	1.702 ml	3.403 ml
10 mM	0.17 ml	0.851 ml	1.702 ml
50 mM	0.034 ml	0.17 ml	0.34 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(1篇)

1. [IF=12.4] Yuting Lin et al."Microenvironment-induced CREPT expression by cancer-derived small extracellular vesicles primes field cancerization."Theranostics.2024; 14(2): 662–680

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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SCH772984