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• 产品描述： Levobetaxolol hydrochloride is a beta-adrenergic receptor inhibitor (beta blocker), used to lower the pressure in the eye in treating conditions such as glaucoma.

• 靶点： Adrenergic Receptor;AdrenergicReceptor

• 体内研究：
  Levobetaxolol (150 mg/eye) is more potent than dextrobetaxolol, reducing intraocular pressure by 25.9% in conscious ocular hypertensive cynomolgus monkeys. Levobetaxolol (20 mg/kg) significant protects retinal function and results in significantly thicker the RPE and outer nuclear layer in a photic-induced retinopathy rat model. Levobetaxolol (20 mg/kg) results in a 10-fold up-regulation of bFGF and a two-fold up-regulation of CNTF mRNA levels, trophic factors that have been shown to inhibit retinal degeneration in a number of species.

• 参考文献：
  1. Agarwal N, et al. Exp Eye Res, 2002, 74(4), 445-453. 2. Osborne NN, et al. Brain Res Bull, 2004, 62(6), 525-528. 3. Sharif NA, et al. J Ocul Pharmacol Ther, 2001, 17(4), 305-317.

• 溶解性： Soluble  in  DMSO、H2O、Ethanol

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.908 ml	14.54 ml	29.079 ml
  5 mM	0.582 ml	2.908 ml	5.816 ml
  10 mM	0.291 ml	1.454 ml	2.908 ml
  50 mM	0.058 ml	0.291 ml	0.582 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *