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• 产品描述： Remodelin, a specific inhibitor of N-acetyltransferase NAT10, can ameliorate Hutchinson-Gilford Progeria Syndrom (HGPS) cellular phenotypes. Remodelin acts in a progerin- and FTI-independent pathway, by targeting and inhibiting NAT10. NAT10 is a protein with histone acetylation activity and primarily identified to be involved in regulation of telomerase activity

• 靶点： Histone Acetyltransferase;RAAS; HistoneAcetyltransferase

• 体外研究：
  Remodelin blocks invasion and migration of HCC cells in hypoxic conditions

• 体内研究：
  Remodelin (100 mg/kg; p.o) significantly reduces the loss of subcutaneous adipose tissue that is seen in the HGPS mouse model. Animal Model: LmnaG609G/G609G mice (HGPS mice) Dosage: 100 mg/kg Administration: P.o; daily schedule from 3 weeks of age onward, until the end-point (individual weight maxima) Result: Well-tolerated by both genotypes, with no weight loss.

• 参考文献：
  1. Balmus G, et al. Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome. Nat Commun. 2018;9(1):1700. Published 2018 Apr 27. 2. Liu H, et al. DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation. Mol Cell Biochem. 2007;300(1-2):249-258. 3. Ma R, et al. Up regulation of NAT10 promotes metastasis of hepatocellular carcinoma cells through epithelial-to-mesenchymal transition. Am J Transl Res. 2016;8(10):4215-4223. Published 2016 Oct 15.

• 溶解性： soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.753 ml	13.764 ml	27.527 ml
  5 mM	0.551 ml	2.753 ml	5.505 ml
  10 mM	0.275 ml	1.376 ml	2.753 ml
  50 mM	0.055 ml	0.275 ml	0.551 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *