Lificiguat (YC-1) 99%

3-(5-Hydroxymethyl-2-Furyl)-1-Benzylindazole

源叶(MedMol)
S81394
170632-47-0
C19H16N2O2
304.343
2-Furanmethanol,5-[1-(phenylmethyl)-1H-indazol-3-yl]; 1-benzyl-3-(5-hydroxymethyl-furan-2-yl)indazole; 5-[1-(PHENYLMETHYL)-1H-INDAZOL-3-YL]-2-FURANMETHANOL; (5-(1-Benzyl-1H-indazol-3-yl)furan-2-yl)Met
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S81394-2mg 99% ¥100.00元 2 - - -
源叶(MedMol) S81394-5mg 99% ¥180.00元 预计交期:2-3天 - - -
源叶(MedMol) S81394-10mg 99% ¥240.00元 4 - - -
源叶(MedMol) S81394-25mg 99% ¥420.00元 预计交期:2-3天 - - -
源叶(MedMol) S81394-50mg 99% ¥680.00元 预计交期:2-3天 - - -
源叶(MedMol) S81394-100mg 99% ¥1100.00元 预计交期:2-3天 - - -
源叶(MedMol) S81394-250mg 99% ¥1800.00元 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Lificiguat binds to the β subunit of soluble guanylyl cyclase(sGC) with Kd of 0.6-1.1 μM in the presence of CO.
产品描述: Lificiguat binds to the β subunit of soluble guanylyl cyclase(sGC) with Kd of 0.6-1.1 μM in the presence of CO.
靶点: Kd: 0.6-1.1 μM (sGC, in the presence of CO);Others; Guanylatecyclase; HIF
体内研究: Lificiguat (YC-1) (30 or 60 mg/kg, i.p.) inhibits MDA-MB-468 tumor growth in a dose-dependent manner. The effect of the prodrug formulation of Lificiguat (YC-1), YC-1-S, in MDA-MB-468 tumor-bearing mice is also investigated. In vivo pharmacokinetic analysis reveal that YC-1-S is quickly converted into its active form. Mice are administered 20, 40 or 80 mg/kg YC-1-S p.o. YC-1-S also displays dose-dependent inhibition of MDA-MB468 tumor growth. Both Lificiguat (YC-1) and YC-1-S dose-dependently reduce tumor weight. Moreover, the mean body weight of mice is not affected by Lificiguat (YC-1) or YC-1-S compare with vehicle-treated groups. Lificiguat (YC-1) is a potent NO-GC activator reported to improve rodent learning behavior when examined with the Morris water maze (MWM) and avoidance tests. Lificiguat (YC-1) enhances long-term potentiation (LTP) in hippocampal Schafer collateral-CA1 synapse via the NO-cGMP-PKG-dependent pathway and potentiated LTP induction in the amygdala, increases the activation of ERK, and potentiated the expression of brain-derived neurotrophic factor (BDNF) cAMP response element-binding protein (CREB) in response to fear memory test.
参考文献: 1. Purohit R, et al. YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit. Biochemistry. 2014 Jan 14;53(1):101-14. 2. Kong J, et al. YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma. Mol Cancer. 2014 Jan 13;13:7. 3. Chang LC, et al. YC-1 inhibits proliferation of breast cancer cells by down-regulating EZH2 expression via activation of c-Cbl and ERK. Br J Pharmacol. 2014 Sep;171(17):4010-25. 4. Komsuoglu Celikyurt I, et al. Effects of YC-1 on Learning and Memory Functions of Aged Rats. Med Sci Monit Basic Res. 2014 Aug 21;20:130-7.
溶解性: DMSO  :  ≥  100  mg/mL  (328.58  mM)
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 3.286 ml 16.429 ml 32.858 ml
5 mM 0.657 ml 3.286 ml 6.572 ml
10 mM 0.329 ml 1.643 ml 3.286 ml
50 mM 0.066 ml 0.329 ml 0.657 ml
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