源叶(MedMol)
S81394
一键复制产品信息
170632-47-0
C19H16N2O2
304.343
2-Furanmethanol,5-[1-(phenylmethyl)-1H-indazol-3-yl]; 1-benzyl-3-(5-hydroxymethyl-furan-2-yl)indazole; 5-[1-(PHENYLMETHYL)-1H-INDAZOL-3-YL]-2-FURANMETHANOL; (5-(1-Benzyl-1H-indazol-3-yl)furan-2-yl)Met
Lificiguat (YC-1) 99.90%
| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81394-2mg买3赠1 |
99.90% | ￥100.00 |
2 | - | 2 | - | - |
|
S81394-5mg买3赠1 |
99.90% | ￥180.00 |
8 | - | - | - | - |
|
S81394-10mg买3赠1 |
99.90% | ￥240.00 |
1 | - | - | - | - |
|
S81394-25mg买3赠1 |
99.90% | ￥420.00 |
5 | - | - | - | - |
|
S81394-50mg买3赠1 |
99.90% | ￥680.00 |
2 | - | - | - | - |
|
S81394-100mg买3赠1 |
99.90% | ￥1100.00 |
3 | - | - | - | - |
|
S81394-250mg |
≥99% | ￥1800.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | Lificiguat binds to the β subunit of soluble guanylyl cyclase(sGC) with Kd of 0.6-1.1 μM in the presence of CO. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | Kd: 0.6-1.1 μM (sGC, in the presence of CO);Others; Guanylatecyclase; HIF | ||||||||||||||||||||
| 体内研究： | Lificiguat (YC-1) (30 or 60 mg/kg, i.p.) inhibits MDA-MB-468 tumor growth in a dose-dependent manner. The effect of the prodrug formulation of Lificiguat (YC-1), YC-1-S, in MDA-MB-468 tumor-bearing mice is also investigated. In vivo pharmacokinetic analysis reveal that YC-1-S is quickly converted into its active form. Mice are administered 20, 40 or 80 mg/kg YC-1-S p.o. YC-1-S also displays dose-dependent inhibition of MDA-MB468 tumor growth. Both Lificiguat (YC-1) and YC-1-S dose-dependently reduce tumor weight. Moreover, the mean body weight of mice is not affected by Lificiguat (YC-1) or YC-1-S compare with vehicle-treated groups. Lificiguat (YC-1) is a potent NO-GC activator reported to improve rodent learning behavior when examined with the Morris water maze (MWM) and avoidance tests. Lificiguat (YC-1) enhances long-term potentiation (LTP) in hippocampal Schafer collateral-CA1 synapse via the NO-cGMP-PKG-dependent pathway and potentiated LTP induction in the amygdala, increases the activation of ERK, and potentiated the expression of brain-derived neurotrophic factor (BDNF) cAMP response element-binding protein (CREB) in response to fear memory test. | ||||||||||||||||||||
| 参考文献： | 1. Purohit R, et al. YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit. Biochemistry. 2014 Jan 14;53(1):101-14. 2. Kong J, et al. YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma. Mol Cancer. 2014 Jan 13;13:7. 3. Chang LC, et al. YC-1 inhibits proliferation of breast cancer cells by down-regulating EZH2 expression via activation of c-Cbl and ERK. Br J Pharmacol. 2014 Sep;171(17):4010-25. 4. Komsuoglu Celikyurt I, et al. Effects of YC-1 on Learning and Memory Functions of Aged Rats. Med Sci Monit Basic Res. 2014 Aug 21;20:130-7. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 100 mg/mL (328.58 mM) | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
参考文献
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