| 产品描述： | Y-33075 dihydrochloride is a selective ROCK inhibitor with an IC50 of 3.6 nM. |
| 靶点： |
ROCK:3.6 nM (IC50);PKC:420 nM (IC50);CaMKII:810 nM (IC50) |
| 体内研究： |
In rabbits, Y-39983 (≥0.01%) significantly lowers intraocular pressure (IOP) at 2 hours after topical administration. In monkeys, Y-39983 (0.05%)-treated eyes show significant reduction of IOP between 2 and 7 hours after topical administration. Y-39983 (100 μM) increases the regenerating axons of retinal ganglion cells (RGCs) in the eyes of the rats |
| 参考文献： |
1. Hideki Tokushige, et al. Effects of Topical Administration of Y-39983, a Selective Rho-Associated Protein Kinase Inhibitor, on Ocular Tissues in Rabbits and Monkeys Invest. Ophthalmol. Vis. Sci. July 2007 vol. 48no. 7 3216-3222 2. Tokushige H, et al. Effects of Y-39983, a selective Rho-associated protein kinase inhibitor, on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats. Curr Eye Res. 2011 Oct;36(10):964-70. 3. Watabe H, et al. Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries.Jpn J Ophthalmol. 2011 Jul;55(4):411-7. Epub 2011 Jun 11. |
| 溶解性： |
DMSO : 100 mg/mL (283.09 mM; Need ultrasonic) H2O : 50 mg/mL (141.54 mM; Need ultrasonic) |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.831 ml |
14.154 ml |
28.309 ml |
| 5 mM |
0.566 ml |
2.831 ml |
5.662 ml |
| 10 mM |
0.283 ml |
1.415 ml |
2.831 ml |
| 50 mM |
0.057 ml |
0.283 ml |
0.566 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京