货号	规格	价格	上海	北京	武汉	南京
S81416-5mg	98%	￥680.00 S81416-5mg ￥680.00 现货	18 >10	-	-	-
S81416-10mg	98%	￥1122.00 S81416-10mg ￥1122.00 2-3天	0 货期：2-3天	-	-	-
S81416-25mg	98%	￥2050.00 S81416-25mg ￥2050.00 2-3天	0 货期：2-3天	-	-	-

货号

规格

价格

上海

北京

武汉

南京

购买数量

S81416-5mg

98%

￥680.00

>10

S81416-10mg

98%

￥1122.00

货期：2-3天

S81416-25mg

98%

￥2050.00

货期：2-3天

产品介绍

BI-7273 is a selective, and cell-permeable BRD9 inhibitor, with an IC50 and a Kd of 19 and 0.75 nM; also shows high effect on BRD7, with an IC50 and a Kd of 117 nM and 0.3 nM.

产品描述：

BI-7273 is a selective, and cell-permeable BRD9 inhibitor, with an IC50 and a Kd of 19 and 0.75 nM; also shows high effect on BRD7, with an IC50 and a Kd of 117 nM and 0.3 nM.

靶点：

IC50: 19 nM (BRD9), 117 nM (BRD7) Kd: 0.75 nM (BRD9), 0.3 nM (BRD7);EpigeneticReaderDomain

体外研究：

BI-7273 is a selective, and cell-permeable BRD9 inhibitor, with an IC50 and a Kd of 19 and 0.75 nM; also shows high effect on BRD7, with an IC50 and a Kd of 117 nM and 0.3 nM. BI-7273 also has slight activity against a panel of kinases such as CECR2, BRPF1, BRD1, CREBBP, EP300, FALZ, TAF1(2) and TAF1L(2), with Kds of 8.8 nM, 210 nM, 2600 nM, 8600 nM, 10000 nM, 850 nM, 1000 nM, and 1200 nM, respectively. BI-7273 (1 μM) is active in U2OS cell lines. BI-7273 blocks EOL-1 cell proliferation with EC50 of 1400 nM

参考文献：

1. Martin LJ, et al. Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor. J Med Chem. 2016 May 26;59(10):4462-75.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.83 ml	14.148 ml	28.295 ml
5 mM	0.566 ml	2.83 ml	5.659 ml
10 mM	0.283 ml	1.415 ml	2.83 ml
50 mM	0.057 ml	0.283 ml	0.566 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

BI-7273