| 品牌 | 货号 | 产品规格 | 价格(RMB) | 库存（上海） | 北京 | 武汉 | 南京 | 购买数量 |
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| 源叶(MedMol) | S81416-5mg | 98% | ￥680.00元 | >10 | - | - | - |
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| 源叶(MedMol) | S81416-10mg | 98% | ￥1122.00元 | 预计交期：2-3天 | - | - | - |
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| 源叶(MedMol) | S81416-25mg | 98% | ￥2050.00元 | 预计交期：2-3天 | - | - | - |
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| 产品描述： BI-7273 is a selective, and cell-permeable BRD9 inhibitor, with an IC50 and a Kd of 19 and 0.75 nM; also shows high effect on BRD7, with an IC50 and a Kd of 117 nM and 0.3 nM. | ||||||||||||||||||||
| 靶点： IC50: 19 nM (BRD9), 117 nM (BRD7) Kd: 0.75 nM (BRD9), 0.3 nM (BRD7);EpigeneticReaderDomain | ||||||||||||||||||||
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体外研究： BI-7273 is a selective, and cell-permeable BRD9 inhibitor, with an IC50 and a Kd of 19 and 0.75 nM; also shows high effect on BRD7, with an IC50 and a Kd of 117 nM and 0.3 nM. BI-7273 also has slight activity against a panel of kinases such as CECR2, BRPF1, BRD1, CREBBP, EP300, FALZ, TAF1(2) and TAF1L(2), with Kds of 8.8 nM, 210 nM, 2600 nM, 8600 nM, 10000 nM, 850 nM, 1000 nM, and 1200 nM, respectively. BI-7273 (1 μM) is active in U2OS cell lines. BI-7273 blocks EOL-1 cell proliferation with EC50 of 1400 nM |
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参考文献： 1. Martin LJ, et al. Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor. J Med Chem. 2016 May 26;59(10):4462-75. |
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| 溶解性： soluble in DMSO | ||||||||||||||||||||
| 保存条件： -20℃ | ||||||||||||||||||||
配置溶液浓度参考：
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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