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AMI-1 99%

Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)

MedMol
S81428
20324-87-2
C21H14N2Na2O9S2
548.45
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
MedMol S81428-2mg 99% ¥240.00元 9 - - -
MedMol S81428-5mg 99% ¥385.00元 10 - - -
MedMol S81428-10mg 99% ¥660.00元 8 - - -
MedMol S81428-25mg 99% ¥1160.00元 9 - - -
MedMol S81428-50mg 99% ¥1810.00元 6 - - -
MedMol S81428-100mg 99% ¥3000.00元 3 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

AMI-1 is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 exerts PRMTs inhibitory effects by blocking peptide-substrate binding
产品描述: AMI-1 is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 exerts PRMTs inhibitory effects by blocking peptide-substrate binding
靶点: IC50: 8.8 μM (PRMT1), 3.0 μM (yeast-Hmt1p);HistoneMethyltransferase
体内研究:
AMI-1 (0.5 mg; intratumorally; daily; for 7 days) inhibits S180 viability in vivo. AMI-1 (0.5 mg; intratumorally; daily; for 7 days) downregulates PRMT5 but does not regulate the expression of PRMT7 in a tumor xenograft model. AMI-1 (0.5 mg; intratumorally; daily; for 7 days) decreases the levels of H4R3me2s and H3R8me2s in a tumor xenograft model
参考文献:
1. Zhang, B., et al. Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3. Oncotarget. 2015 Sep 8;6(26):22799-811. 2. Baolai Zhang, et al. Arginine Methyltransferase inhibitor-1 Inhibits Sarcoma Viability in vitro and in vivo. Oncol Lett. 2018 Aug;16(2):2161-2166. 3. Donghang Cheng, et al. Small Molecule Regulators of Protein Arginine Methyltransferases. J Biol Chem. 2004 Jun 4;279(23):23892-9.
溶解性: H2O  :  62.5  mg/mL  (113.96  mM;  ultrasonic  and  warming  and  heat  to  60°C)
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 1.823 ml 9.117 ml 18.233 ml
5 mM 0.365 ml 1.823 ml 3.647 ml
10 mM 0.182 ml 0.912 ml 1.823 ml
50 mM 0.036 ml 0.182 ml 0.365 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

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