货号	规格	价格	上海	北京	武汉	南京	购买数量
S81487-1mg	98%	￥559.00 S81487-1mg ￥559.00 2-3天	0 货期：2-3天	-	-	-
S81487-5mg	98%	￥1344.00 S81487-5mg ￥1344.00 2-3天	0 货期：2-3天	-	-	-

产品介绍

Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1.

产品描述：

Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1.

靶点：

HDAC;Virus Protease;VirusProtease; HDAC

体内研究：

In chick embryos, inhibition of HDAC6 activity by Tubacin reduces the formation of new blood vessels in matrigel/nylon mesh. In angioreactors implanted in mice, Tubacin also impairs the formation of new blood vessels.

细胞实验：

Cell lines: Drug-sensitive (MM.1S,U266,INA-6,and RPMI8226) and drug-resistant (RPMI-LR5 and RPMI-Dox40) MM cell lines. Concentrations: ~20 μM. Incubation Time: 72 hours. Method:The inhibitory effect of bortezomib and/or tubacin on MM cell growth is assessed by measuring 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) dye absorbance.All experiments are performed in quadruplicate.

动物实验：

Animal Models: Athymic nude mice implanted with angioreactorsFormulation: DMSODosages: --Administration: Tubacin is filled in semiclosed angioreactors, and then implanted into the mice.

参考文献：

1. Li D, et al. Protein Cell. 2011, 2(2), 150-160. 2. Butler KV, et al. J Am Chem Soc. 2010, 132(31), 10842-0846. 3. Hideshima T, et al. Proc Natl Acad Sci U S A. 2005, 102(24), 8567-8572. 4. Marcus AI, et al. Cancer Res. 2005, 65(9), 3883-3893. 5. Lu CY, et al. Tubacin, an HDAC6 Selective Inhibitor, Reduces the Replication of the Japanese Encephalitis Virus via the Decrease of Viral RNA Synthesis. Int J Mol Sci. 2017 May 1;18(5). 6. Haggarty SJ, et al. Proc Natl Acad Sci U S A. 2003, 100(8), 4389-4394.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.385 ml	6.927 ml	13.853 ml
5 mM	0.277 ml	1.385 ml	2.771 ml
10 mM	0.139 ml	0.693 ml	1.385 ml
50 mM	0.028 ml	0.139 ml	0.277 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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Tubacin