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• 产品描述： Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1.

• 靶点： HDAC;Virus Protease;VirusProtease; HDAC

• 体内研究：
  In chick embryos, inhibition of HDAC6 activity by Tubacin reduces the formation of new blood vessels in matrigel/nylon mesh. In angioreactors implanted in mice, Tubacin also impairs the formation of new blood vessels.

• 细胞实验： Cell lines: Drug-sensitive (MM.1S,U266,INA-6,and RPMI8226) and drug-resistant (RPMI-LR5 and RPMI-Dox40) MM cell lines. Concentrations: ~20 μM. Incubation Time: 72 hours. Method:The inhibitory effect of bortezomib and/or tubacin on MM cell growth is assessed by measuring 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) dye absorbance.All experiments are performed in quadruplicate.

• 动物实验： Animal Models: Athymic nude mice implanted with angioreactorsFormulation: DMSODosages: --Administration: Tubacin is filled in semiclosed angioreactors, and then implanted into the mice.

• 参考文献：
  1. Li D, et al. Protein Cell. 2011, 2(2), 150-160. 2. Butler KV, et al. J Am Chem Soc. 2010, 132(31), 10842-0846. 3. Hideshima T, et al. Proc Natl Acad Sci U S A. 2005, 102(24), 8567-8572. 4. Marcus AI, et al. Cancer Res. 2005, 65(9), 3883-3893. 5. Lu CY, et al. Tubacin, an HDAC6 Selective Inhibitor, Reduces the Replication of the Japanese Encephalitis Virus via the Decrease of Viral RNA Synthesis. Int J Mol Sci. 2017 May 1;18(5). 6. Haggarty SJ, et al. Proc Natl Acad Sci U S A. 2003, 100(8), 4389-4394.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.385 ml	6.927 ml	13.853 ml
  5 mM	0.277 ml	1.385 ml	2.771 ml
  10 mM	0.139 ml	0.693 ml	1.385 ml
  50 mM	0.028 ml	0.139 ml	0.277 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *