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• 产品描述： Oxfendazole, a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.

• 靶点： Glucokinase;Microtubule Associated;Parasite;Glucokinase; MicrotubuleAssociated; Parasite

• 体内研究：
  Oxfendazole (OX) induces not only mRNA expression of phase I enzymes Cyp1a1, Cyp1a2, but also Nrf2-regulated phase II enzymes such as Gpx2, Nqo1, Yc2, Akr7a3 and Gstm1 in rats, presumably due to an adaptive response against OX-induced oxidative stress. Oxfendazole enhances oxidative DNA damage (as assessed by 8-hydroxydeoxyguanosine; 8-OHdG) and lipid peroxidation (as assessed by thiobarbituric acid-reactive substances; TBARS) in rats. Oxfendazole administered at the therapeutic dose (4.5 mg/kg) and at the highest dose (22.5 mg/kg) increase 1.54- and 2.36-fold the total liver microsomal cytochrome P450 and more particularly the isoenzyme P450IA2 (95% and 184% increases) in rabbit liver. Oxfendazole MRL induces a mutagenic effect in all tested cell types. Oxfendazole exhibits embryotoxicity including teratogenicity. Oxfendazole induces a disturbance in the different biochemical contents of all tested tissues in mice. Oxfendazole increases the incidence and multiplicity of altered foci (4.0- and 3.6-fold, respectively) and hepatocellular adenomas (HCAs) (3.0- and 5.5-fold, respectively). Oxfendazole treatment induces 5.2- and 5.6-fold increases in the number of proliferating cell nuclear antigen (PCNA)-positive cells and single-stranded DNA (ssDNA)-positive cells in HCAs compared with the surrounding tissue, respectively. Oxfendazole and its sulphone metabolite attain a significantly higher plasma concentration and remain much longer in plasma compared with fenbendazole (FBZ) and albendazole (ABZ) and

• 参考文献：
  1.Dewa Y, et al. Arch Toxicol,2009, 83(5), 503-511. 2.Dewa Y, et al. Arch Toxicol,2011, 85(2), 155-162. 3.El-Makawy A, et al. Reprod Nutr Dev,2006, 46(2), 139-156. 4.Gokbulut C, et al. Vet Parasitol,2007, 148(3-4), 279-287. 5.Gleizes C, et al. Biochem Pharmacol,1991, 41(12), 1813-1820.

• 溶解性： Ethanol:<1  mg/mL    H2O:<1  mg/mL    DMSO:10  mg/mL  (31.71  mM)

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.171 ml	15.855 ml	31.711 ml
  5 mM	0.634 ml	3.171 ml	6.342 ml
  10 mM	0.317 ml	1.586 ml	3.171 ml
  50 mM	0.063 ml	0.317 ml	0.634 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *