货号	规格	价格	上海	北京	武汉	南京
S81507-100mg	99%	￥100.00 S81507-100mg ￥100.00 现货	7 7	-	-	-
S81507-500mg	99%	￥240.00 S81507-500mg ￥240.00 现货	8 8	-	-	-
S81507-1g	99%	￥400.00 S81507-1g ￥400.00 现货	4 4	-	-	-

产品介绍

Amodiaquine dihydrochloride dihydrate (Amodiaquin dihydrochloride dihydrate), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine dihydrochloride dihydrate is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect

产品描述：

靶点：

EC50: ~20 μM (Nurr1-LBD (ligand binding domain)) Histamine N-methyltransferase;HistoneMethyltransferase; Parasite; HistamineReceptor

体内研究：

Amodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice

参考文献：

1. Chun-Hyung Kim, et al. Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8756-61. 2. Keita Kinoshita, et al. A Nurr1 agonist amodiaquine attenuates inflammatory events and neurological deficits in a mouse model of intracerebral hemorrhage. J Neuroimmunol. 2019 May 15;330:48-54. 3. Akira Yokoyama, et al. Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice. Eur J Pharmacol. 2007 Mar 8;558(1-3):179-84. 4. M T HOEKENGA. The treatment of acute malaria with single oral doses of amodiaquin, chloroquine, hydroxychloroquine and pyrimethamine. Am J Trop Med Hyg. 1954 Sep;3(5):833-8.

溶解性：

DMSO : 100 mg/mL (215.14 mM; Need ultrasonic) H2O : 20 mg/mL (43.03 mM; Need ultrasonic)

保存条件：

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.151 ml	10.757 ml	21.514 ml
5 mM	0.43 ml	2.151 ml	4.303 ml
10 mM	0.215 ml	1.076 ml	2.151 ml
50 mM	0.043 ml	0.215 ml	0.43 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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Amodiaquine dihydrochloride dihydrate

Amodiaquine Dihydrochloride Dihydrate