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S81507

Amodiaquine dihydrochloride dihydrate

源叶(MedMol) 99%
  • 英文名:
  • Amodiaquine Dihydrochloride Dihydrate
  • 别名:
  • CAS号:
  • 6398-98-7
  • 分子式:
  • C20H28Cl3N3O3
  • 分子量:
  • 464.81
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源叶(MedMol) S81507-100mg 99% ¥100.00元 7 - - - EA 加入购物车
源叶(MedMol) S81507-500mg 99% ¥240.00元 8 - - - EA 加入购物车
源叶(MedMol) S81507-1g 99% ¥400.00元 4 - - - EA 加入购物车
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质检证书(COA)

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  • 提示:详情请下载说明书。
  • 产品描述: Amodiaquine dihydrochloride dihydrate (Amodiaquin dihydrochloride dihydrate), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine dihydrochloride dihydrate is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect
  • 靶点: EC50: ~20 μM (Nurr1-LBD (ligand binding domain)) Histamine N-methyltransferase;HistoneMethyltransferase; Parasite; HistamineReceptor
  • 体内研究:
    Amodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice
  • 参考文献:
    1. Chun-Hyung Kim, et al. Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8756-61. 2. Keita Kinoshita, et al. A Nurr1 agonist amodiaquine attenuates inflammatory events and neurological deficits in a mouse model of intracerebral hemorrhage. J Neuroimmunol. 2019 May 15;330:48-54. 3. Akira Yokoyama, et al. Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice. Eur J Pharmacol. 2007 Mar 8;558(1-3):179-84. 4. M T HOEKENGA. The treatment of acute malaria with single oral doses of amodiaquin, chloroquine, hydroxychloroquine and pyrimethamine. Am J Trop Med Hyg. 1954 Sep;3(5):833-8.
  • 溶解性: DMSO  :  100  mg/mL  (215.14  mM;  Need  ultrasonic)    H2O  :  20  mg/mL  (43.03  mM;  Need  ultrasonic)
  • 保存条件: RT
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 2.151 ml 10.757 ml 21.514 ml
    5 mM 0.43 ml 2.151 ml 4.303 ml
    10 mM 0.215 ml 1.076 ml 2.151 ml
    50 mM 0.043 ml 0.215 ml 0.43 ml
  • 注意:部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)


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