EHT 1864

    
99%

EHT 1864

源叶(MedMol)
S81529 一键复制产品信息
754240-09-0
C25H29Cl2F3N2O4S
581.47
货号 规格 价格 上海 北京 武汉 南京 购买数量
S81529-5mg 99% ¥442.00 6 - - -
S81529-10mg 99% ¥822.80 7 - - -
S81529-25mg 99% ¥1836.00 10 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

EHT 1864 is a effective Rac family GTPase inhibitor for Rac1/Rac1b/Rac2/Rac3 (Kd: 40/50/60/250 nM).

产品描述: EHT 1864 is a effective Rac family GTPase inhibitor for Rac1/Rac1b/Rac2/Rac3 (Kd: 40/50/60/250 nM).
靶点: Ras;Rho;Rho; Ras
体内研究: EHT 1864 (40 mg/kg i.p.) significantly reduces Abeta 40 and Abeta 42 levels in guinea pig brains.
细胞实验: NIH 3T3 cells stably expressing oncogenic Ras are plated in 96-well plates. The cells are cultured for up to 4 days in complete growth medium, either alone, or supplemented with 5 μM EHT 1864. Cell growth is then assessed using the conversion of MTT to a formazan product. Briefly, the MTT reagent (from a 5 mg/ml solution diluted in PBS) is added to the wells at a final concentration of 0.5 mg/ml, and the cells are further incubated for 4 h at 37°C. The medium is then removed, and the reaction is terminated by adding 100 μl/well Me2SO. The absorbance is read at 570 nm using a microplate reader.(Only for Reference)
参考文献: 1.Shutes A, et al. J Biol Chem. 2007, 282(49), 35666-35678. 2.Raynaud F, et al. J Biol Chem. 2014, 289(5), 2600-2609. 3.Liu X, Wang S, Zheng H, et al. Epimedokoreanin C, A Prenylated Flavonoid Isolated from Epimedium Koreanum, Induces Non-Apoptotic Cell Death with the Characteristics of Methuosis in Lung Cancer Cells[J]. 2020 4.Désiré L, et al. J Biol Chem. 2005, 280(45), 37516-3752
溶解性: DMSO:43.6  mg/mL  (75  mM)    H2O:58.2  mg/mL  (100  mM)
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 1.72 ml 8.599 ml 17.198 ml
5 mM 0.344 ml 1.72 ml 3.44 ml
10 mM 0.172 ml 0.86 ml 1.72 ml
50 mM 0.034 ml 0.172 ml 0.344 ml
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参考文献

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