货号	规格	价格	上海	北京	武汉	南京
S81529-5mg	99%	￥442.00 S81529-5mg ￥442.00 现货	6 6	-	-	-
S81529-10mg	99%	￥822.80 S81529-10mg ￥822.80 现货	7 7	-	-	-
S81529-25mg	99%	￥1836.00 S81529-25mg ￥1836.00 现货	10 10	-	-	-

产品介绍

EHT 1864 is a effective Rac family GTPase inhibitor for Rac1/Rac1b/Rac2/Rac3 (Kd: 40/50/60/250 nM).

产品描述：

EHT 1864 is a effective Rac family GTPase inhibitor for Rac1/Rac1b/Rac2/Rac3 (Kd: 40/50/60/250 nM).

靶点：

Ras;Rho;Rho; Ras

体内研究：

EHT 1864 (40 mg/kg i.p.) significantly reduces Abeta 40 and Abeta 42 levels in guinea pig brains.

细胞实验：

NIH 3T3 cells stably expressing oncogenic Ras are plated in 96-well plates. The cells are cultured for up to 4 days in complete growth medium, either alone, or supplemented with 5 μM EHT 1864. Cell growth is then assessed using the conversion of MTT to a formazan product. Briefly, the MTT reagent (from a 5 mg/ml solution diluted in PBS) is added to the wells at a final concentration of 0.5 mg/ml, and the cells are further incubated for 4 h at 37°C. The medium is then removed, and the reaction is terminated by adding 100 μl/well Me2SO. The absorbance is read at 570 nm using a microplate reader.(Only for Reference)

参考文献：

1.Shutes A, et al. J Biol Chem. 2007, 282(49), 35666-35678. 2.Raynaud F, et al. J Biol Chem. 2014, 289(5), 2600-2609. 3.Liu X, Wang S, Zheng H, et al. Epimedokoreanin C, A Prenylated Flavonoid Isolated from Epimedium Koreanum, Induces Non-Apoptotic Cell Death with the Characteristics of Methuosis in Lung Cancer Cells[J]. 2020 4.Désiré L, et al. J Biol Chem. 2005, 280(45), 37516-3752

溶解性：

DMSO:43.6 mg/mL (75 mM) H2O:58.2 mg/mL (100 mM)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.72 ml	8.599 ml	17.198 ml
5 mM	0.344 ml	1.72 ml	3.44 ml
10 mM	0.172 ml	0.86 ml	1.72 ml
50 mM	0.034 ml	0.172 ml	0.344 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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浓度

体积

分子摩尔量

计算重置

EHT 1864