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• 产品描述： EHT 1864 is a effective Rac family GTPase inhibitor for Rac1/Rac1b/Rac2/Rac3 (Kd: 40/50/60/250 nM).

• 靶点： Ras;Rho;Rho; Ras

• 体内研究：
  EHT 1864 (40 mg/kg i.p.) significantly reduces Abeta 40 and Abeta 42 levels in guinea pig brains.

• 细胞实验： NIH 3T3 cells stably expressing oncogenic Ras are plated in 96-well plates. The cells are cultured for up to 4 days in complete growth medium, either alone, or supplemented with 5 μM EHT 1864. Cell growth is then assessed using the conversion of MTT to a formazan product. Briefly, the MTT reagent (from a 5 mg/ml solution diluted in PBS) is added to the wells at a final concentration of 0.5 mg/ml, and the cells are further incubated for 4 h at 37°C. The medium is then removed, and the reaction is terminated by adding 100 μl/well Me2SO. The absorbance is read at 570 nm using a microplate reader.(Only for Reference)

• 参考文献：
  1.Shutes A, et al. J Biol Chem. 2007, 282(49), 35666-35678. 2.Raynaud F, et al. J Biol Chem. 2014, 289(5), 2600-2609. 3.Liu X, Wang S, Zheng H, et al. Epimedokoreanin C, A Prenylated Flavonoid Isolated from Epimedium Koreanum, Induces Non-Apoptotic Cell Death with the Characteristics of Methuosis in Lung Cancer Cells[J]. 2020 4.Désiré L, et al. J Biol Chem. 2005, 280(45), 37516-3752

• 溶解性： DMSO:43.6  mg/mL  (75  mM)    H2O:58.2  mg/mL  (100  mM)

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.72 ml	8.599 ml	17.198 ml
  5 mM	0.344 ml	1.72 ml	3.44 ml
  10 mM	0.172 ml	0.86 ml	1.72 ml
  50 mM	0.034 ml	0.172 ml	0.344 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *