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• 产品描述： AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd of 8.2 nM. AUZ 454 (K03861) inhibits CDK2 activity by competing with binding of activating cyclins

• 靶点： CDK2(C118L/A144C):9.7 nM (Kd);CDK2(A144C):15.4 nM (Kd);CDK2(C118L):18.6 nM (Kd);CDK2(WT):50 nM (Kd);CDK2(C118L/A144C-Cyclin B):134.1 nM (Kd);CDK

• 体外研究：
  AUZ 454 (K03861) (10-20 μM; 1, 2, 3, and 4 days) has a inhibitory effect on Caki-1 and ACHN cells with WTAP overexpression by CCK8 assays. AUZ 454 (K03861) (10 μM; 24 hours) decreases the colony fold in Caki-1 and ACHN cells through a CDK2-dependent mechanism. Cell Proliferation Assay Cell Line: Caki-1 and ACHN cells Concentration: 10 μM; 20 μM Incubation Time: 1, 2, 3, and 4 days Result: Inhibited cell proliferation in a CDK2-dependent manner.

• 参考文献：
  1. Alexander LT et al. Type II Inhibitors Targeting CDK2. ACS Chem Biol. 2015 Sep 18;10(9):2116-25. 2. Tang J,et al. Wilms' tumor 1-associating protein promotes renal cell carcinoma proliferation by regulating CDK2 mRNA stability.J Exp Clin Cancer Res. 2018 Feb 27;37(1):40.

• 溶解性： soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.994 ml	9.97 ml	19.94 ml
  5 mM	0.399 ml	1.994 ml	3.988 ml
  10 mM	0.199 ml	0.997 ml	1.994 ml
  50 mM	0.04 ml	0.199 ml	0.399 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *