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• 产品描述： OF-1 is a potent pan-BRPF bromodomain (BRD) inhibitor, with IC50 values of 270 nM, 1.2 μM for TRIM24 and BRPF1B, respectively

• 靶点： Epigenetic Reader Domain;EpigeneticReaderDomain

• 体外研究：
  OF-1 (1 μM and 2 μM, 0, 1, 2, and 3 days) causes significant reductions in the number of multinucleated tartrate-resistant acid phosphatase (TRAP) positive cells. OF-1 is the only inhibitor to completely suppress the fusion into multinucleated “osteoclast-like” cells. Cell Viability Assay Cell Line: Murine BMCs during differentiation with 10 ng/mL RANKL. Concentration: 1 μM and 2 μM. Incubation Time: 0, 1, 2, and 3 days. Result: Particularly strong at day 2 after RANKL-induced differentiation.

• 参考文献：
  1. Julia C Meier, et al. Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation. ACS Chem Biol. 2017 Oct 20;12(10):2619-2630. 2. James Bennett, et al. Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF. J Med Chem. 2016 Feb 25;59(4):1642-7.

• 溶解性： soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.271 ml	11.356 ml	22.711 ml
  5 mM	0.454 ml	2.271 ml	4.542 ml
  10 mM	0.227 ml	1.136 ml	2.271 ml
  50 mM	0.045 ml	0.227 ml	0.454 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *