PDK1 inhibitor

≥99%

PDK1 inhibitor

产品说明书产品使用指南

品牌：源叶(MedMol)

产品编号：S81603 一键复制产品信息

CAS号：1001409-50-2

分子式：C₂₈H₂₂F₂N₄O₄

分子量：516.4955

别名：CS-0709; MP7; 1-(3,4-Difluorobenzyl)-2-Oxo-N-{(1r)-2-[(2-Oxo-2,3-Dihydro-1h-Benzimidazol-5-Yl)oxy]-1-Phenylethyl}-1,2-Dihydropyridine-3-Carboxamide; 3qc4; PDK1 inhibitor;

货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S81603-5mg	≥99%	￥1070.00 S81603-5mg ￥1070.00 3-5天	0 货期：3-5天	-	-	-	-
S81603-10mg	≥99%	￥1730.00 S81603-10mg ￥1730.00 3-5天	0 货期：3-5天	-	-	-	-

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产品介绍参考文献质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

MP7 (PDK1 inhibitor) is a phosphoinositide-dependent kinase-1 (PDK1) inhibitor.

靶点：

PDK1;PDK

体外研究：

Cell counting of U87MG-derived glioma stem cells (GSCs) confirms that Alisertib and, to a minor extent, MP7 (PDK1 inhibitor) are able to decrease the number of viable cells. When combined together, GSC viability is further reduced with respect to single-treated cells. As observed in U87MG cells, when used at the highest concentrations (i.e., 1.5 μM Alisertib and 2.5 μM MP7), a significant enhancement in the number of dead cells is evidenced. Following 72 h treatment, MP7 alone does not show a significant inhibition of glioblastoma multiforme (GBM) proliferation. MP7 has been shown to have only minimal effects on monolayer cell growth in several cancer cell lines, with IC50 values in the micromolar range

参考文献：

1. Daniele S, et al. Dual Inhibition of PDK1 and Aurora Kinase A: An Effective Strategy to Induce Differentiation and Apoptosis of Human Glioblastoma Multiforme Stem Cells. ACS Chem Neurosci. 2017 Jan 18;8(1):100-114.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.936 ml	9.681 ml	19.361 ml
5 mM	0.387 ml	1.936 ml	3.872 ml
10 mM	0.194 ml	0.968 ml	1.936 ml
50 mM	0.039 ml	0.194 ml	0.387 ml