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• 产品描述： GSK4716 is an ERRβ/γ agonist (IC50 = 2 μM) that can activate the receptor with similar potency as the protein ligand

• 靶点： Estrogen Receptor/ERR;EstrogenReceptor/ERR

• 细胞实验： Mouse myoblasts were isolated as described previously.?Human ERRγ-IRES green fluorescent protein adenovirus was generated by Welgen.?Following a 48-h differentiation period, myotubes were transduced with green fluorescent protein or ERRγ adenovirus for 48 h. The titers to achieve low and high levels of ERRγ expression were 1* 10^8 and 5*10^8 virus particles/ml, respectively.?GSK4716 was synthesized as described previously and dissolved in DMSO for cell culture experiments.?Cells treated with a corresponding volume of DMSO were used as controls

• 参考文献：
  1.Wang L , Zuercher W J , Consler T G , et al. X-ray Crystal Structures of the Estrogen-related Receptor-? Ligand Binding Domain in Three Functional States Reveal the Molecular Basis of Small Molecule Regulation[J]. Journal of Biological Chemistry, 2006, 281(49):37773-37781. 2.Wang SC, et al. An ERRbeta/gamma agonist modulates GRalpha expression, and glucocorticoid responsive gene expression in skeletal muscle cells. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):146-52. 3.Rangwala S M , Wang X , Calvo J A , et al. Estrogen-related Receptor ? Is a Key Regulator of Muscle Mitochondrial Activity and Oxidative Capacity[J]. Journal of Biological Chemistry, 2010, 285(29):22619-22629.

• 溶解性： DMSO:100  mg/mL  (354.18  mM)

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.542 ml	17.709 ml	35.418 ml
  5 mM	0.708 ml	3.542 ml	7.084 ml
  10 mM	0.354 ml	1.771 ml	3.542 ml
  50 mM	0.071 ml	0.354 ml	0.708 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *