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S82154

BTZ043

源叶(MedMol) 98%
  • 英文名:
  • BTZ043
  • 别名:
  • BTZ-043; UNII-G55ZH52P57; BTZ043;
  • CAS号:
  • 1161233-85-7
  • 分子式:
  • C17H16F3N3O5S
  • 分子量:
  • 431.3862496
  • 核磁/质谱:
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S82154-1mg 98% ¥197.20元 9 - - - EA 加入购物车
源叶(MedMol) S82154-2mg 98% ¥353.60元 10 - - - EA 加入购物车
源叶(MedMol) S82154-5mg 98% ¥612.00元 7 - - - EA 加入购物车
源叶(MedMol) S82154-10mg 98% ¥1054.00元 6 - - - EA 加入购物车
源叶(MedMol) S82154-25mg 98% ¥1904.00元 5 - - - EA 加入购物车
源叶(MedMol) S82154-50mg 98% ¥3400.00元 预计交期:2-3天 - - - EA 加入购物车
源叶(MedMol) S82154-100mg 98% ¥5508.00元 预计交期:2-3天 - - - EA 加入购物车
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  • 提示:详情请下载说明书。
  • 产品描述: BTZ043 is an inhibitor of decaprenyl-phosphoribose-epimerase (DprE1), with MICs of of 2.3 nM and 9.2 nM for M. tuberculosis H37Rv and Mycobacterium smegmatis, respectively.
  • 靶点: DprE1;Antibacterial; Antibiotic; DprE1
  • 体外研究:
    The MIC of BTZ043 against M. tuberculosis H37Rv and Mycobacterium smegmatis are 1 ng/mL (2.3 nM) and 4 ng/mL (9.2 nM), respectively. The in vitro activity of BTZ043 against 30 Nocardia brasiliensis isolates is also tested. The MIC50 and MIC90 values for BTZ043 are 0.125 and 0.25 μg/mL. The MIC for N. carnea ATCC 6847 is 0.003μg/mL, for N. transvalensis ATCC 6865 is 0.003μg/mL, for N. brasiliensis NCTC10300 is 0.03 μg/mL, and for N. brasiliensis HUJEG-1 is 0.125μg/mL. The MIC value for M. tuberculosis H37Rv is 0.000976 μg/mL. The MIC value of BTZ-043 is >64 μg/mL for Escherichia coli ATCC 25922 and S. aureus ATCC 29213
  • 体内研究:
    Four weeks of treatment with BTZ043 reduces the bacterial burden in the lungs and spleens by 1 and 2 logs, respectively, at the concentrations used. Additional results suggest that BTZ043 efficacy is time-rather than dose-dependent. Acute (5 g/kg) and chronic (25 and 250 mg/kg) toxicology studies in uninfected mice show that, even at the highest dose tested, there are no adverse anatomical, behavioral, or physiological effects after one month
  • 参考文献:
    1. Vadim Makarov et al. The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 fromMycobacterium tuberculosis. Antimicrob Agents Chemother, 2015 Aug, 59(8): 4446-4452. 2. Makarov V, et al. Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. Science. 2009 May 8;324(5928):801-4. 3. Norma Alejandra González-Martínez et al. In Vivo Activity of the Benzothiazinones PBTZ169 and BTZ043 against Nocardia brasiliensis. PLoS Negl Trop Dis, 2015 Oct, 9(10): e0004022.
  • 溶解性: soluble  in  DMSO
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 2.318 ml 11.591 ml 23.181 ml
    5 mM 0.464 ml 2.318 ml 4.636 ml
    10 mM 0.232 ml 1.159 ml 2.318 ml
    50 mM 0.046 ml 0.232 ml 0.464 ml
  • 注意:部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。
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