ABT-639

    
99%

ABT-639

源叶(MedMol)
S82525 一键复制产品信息
1235560-28-7
C20H20ClF2N3O3S
455.9059
4-氯-2-氟-N-(2-氟苯基)-5-[[(8AR)-六氢吡咯并[1,2-A]吡嗪-2(1H)-基]羰基]苯磺酰胺;4-chloro-2-fluoro-N-(2-fluorophenyl)-5-[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-ylcarbonyl]benzenesulfonamide; ABT-639;
货号 规格 价格 上海 北京 武汉 南京 购买数量
S82525-1mg 99% ¥415.00 10 - - -
S82525-5mg 99% ¥990.00 7 - - -
S82525-10mg 99% ¥1496.00 6 - - -
S82525-25mg 99% ¥3400.00 4 - - -
S82525-50mg 99% ¥5100.00 货期:2-3天 - - -
S82525-100mg 99% ¥7300.00 货期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

ABT-639 is a potent and selective T-type calcium channel blocker.

产品描述: ABT-639 is a potent and selective T-type calcium channel blocker.
靶点: Calcium Channel;CalciumChannel
体外研究: ABT-639 is significantly less active at other Ca2+ channels (e.g. Cav1.2 and Cav2.2) (IC50 > 30 μM). ABT-639 has high oral bioavailability (%F = 73), low protein binding (88.9%) and a low brain:plasma ratio (0.05:1) in rodents.
体内研究: Following oral administration ABT-639 produces dose-dependent antinociception in a rat model of knee joint pain (ED50 = 2 mg/kg, p.o.). ABT-639 (10-100 mg/kg, p.o.) also increases tactile allodynia thresholds in multiple models of neuropathic pain. The antinociceptive profile of ABT-639 provides novel insights into the role of peripheral T-type (Cav3.2) channels in chronic pain states.
参考文献: 1. Jarvis MF, et al. A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats. Biochem Pharmacol. 2014 Jun 15;89(4):536-44.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.193 ml 10.967 ml 21.934 ml
5 mM 0.439 ml 2.193 ml 4.387 ml
10 mM 0.219 ml 1.097 ml 2.193 ml
50 mM 0.044 ml 0.219 ml 0.439 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

如何获取质检证书(COA)?
请输入货号和一个与之匹配的批号。
例如:
批号:JS298415 货号:S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

=
×
×

相关产品