Fatostatin A

99.89%

Fatostatin A

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品牌：源叶(MedMol)

产品编号：S82581 一键复制产品信息

CAS号：125256-00-0

分子式：C₁₈H₁₈N₂S

分子量：294.4139

别名：Hexatype Brown N; Typogen Brown N; Resinol RRN; Solvent Brown 1; fatostatin A; Sudan Brown YR; Sudan Brown RR; Fat Brown RR; 1-naphthylamin->m-phenylendiamin; C.I. Solvent Brown 1; 4-naphthalen-1-yl-d

货号	规格	价格	上海	北京	珠海	重庆	武汉
S82581-5mg	99.89%	￥255.00 S82581-5mg ￥255.00 现货	5 5	-	-	-	-
S82581-10mg	99.89%	￥400.00 S82581-10mg ￥400.00 现货	1 3 1	2	1	-	-
S82581-25mg	99.89%	￥540.00 S82581-25mg ￥540.00 现货	5 5	-	-	-	-
S82581-50mg	99.89%	￥770.00 S82581-50mg ￥770.00 现货	5 5	-	-	-	-
S82581-100mg	99.89%	￥1190.00 S82581-100mg ￥1190.00 现货	4 4	-	-	-	-

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产品介绍参考文献(1篇) 质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

Fatostatin (125B11) 是一种diarylthiazole的衍生物，是 Sterol regulatory element binding proteins (SREBPs) 活化的特异性抑制剂。Fatostatin 可结合SCAP (SREBP cleavage-activating protein)，并抑制SREBP的ER-Golgi易位。Fatostatin 可抑制癌细胞生长并增强癌细胞的凋亡

靶点：

SREBP;NPC1L1; FattyAcidSynthase

体外研究：

Fatostatin impairs the activation process of sterol regulatory element binding proteins (SREBPs), thereby decreasing the transcription of lipogenic genes in cells. Fatostatin inhibits the ER-Golgi translocation of SREBPs through binding to their escort protein, the SREBP cleavage-activating protein (SCAP), at a distinct site from the sterol-binding domain

体内研究：

Fatostatin blocks increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake. Fatostatin may serve as a tool for gaining further insights into the regulation of SREBP

细胞实验：

Cell lines: CHO-K1 cells Concentrations: 20 μM Incubation Time: 20 h Method: CHO-K1 cells are plated out onto a 96-well plate in medium A. The cells are transiently cotransfected with pCMV-PLAP-BP2, pCMV-SCAP, and pAc-b-gal, using Lipofectamine reagent. After incubation for 5 hr, the cells are washed with PBS and then incubated in medium B, in the absence or presence of fatostatin (20 μM) or sterols (10 μg/mL cholesterol and 1 μg/mL 25-hydroxycholesterol). After 20 hr of incubation, an aliquot of the medium is assayed for secreted alkaline phosphatase activity. The cells in each well are lysed and used for measurement of b-galactosidase activities. The alkaline phosphatase activity is normalized by the activity of b-galactosidase.

动物实验：

Animal Models: 4-to-5-week-old homozygous male obese (ob/ob) mice (C57BL/6J) Dosages: 30 mg/kg Administration: IP

参考文献：

1. Shinji Kamisuki, et al. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem Biol. 2009 Aug 28;16(8):882-92. 2. Shuhong Gao, et al. Fatostatin suppresses growth and enhances apoptosis by blocking SREBP-regulated metabolic pathways in endometrial carcinoma. Oncol Rep. 2018 Apr;39(4):1919-1929.

溶解性：

Soluble in DMSO、Ethanol

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.397 ml	16.983 ml	33.966 ml
5 mM	0.679 ml	3.397 ml	6.793 ml
10 mM	0.34 ml	1.698 ml	3.397 ml
50 mM	0.068 ml	0.34 ml	0.679 ml