产品描述: | VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V. |
靶点: |
Cysteine Protease;CysteineProtease |
体外研究: |
VBY-825 is a potent assayed cathepsins inhibitor and its potency against at least one cathepsin, cathepsin S, extends across species relevant for pharmacology studies, specifically mouse. 10 mg/kg/day dose of VBY-825 achieves a trough plasma concentration >200nM, which is well above that required for full inhibition of the intracellular activity of cathepsins B, F, K, L, S and V in both mouse and human cell lines. |
参考文献: |
1. Elie BT, et al. Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model. Biochimie. 2010 Nov;92(11):1618-24. |
溶解性: |
soluble in DMSO |
保存条件: |
-20℃ |
配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
1 mM |
1.867 ml |
9.336 ml |
18.672 ml |
5 mM |
0.373 ml |
1.867 ml |
3.734 ml |
10 mM |
0.187 ml |
0.934 ml |
1.867 ml |
50 mM |
0.037 ml |
0.187 ml |
0.373 ml |
|
注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |