MIR96-IN-1

    
98%

MIR96-IN-1

源叶(MedMol)
S82795 一键复制产品信息
1311982-88-3
C33H48N8O2
588.7866
货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
S82795-1mg 98% ¥1500.00 预计交期:2-3天 - - -
S82795-5mg 98% ¥3500.00 预计交期:2-3天 - - -
S82795-10mg 98% ¥5000.00 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

MIR96-IN-1 targets the Drosha site in the miR-96 (miRNA-96, microRNA-96) hairpin precursor, inhibiting its biogenesis, derepressing downstream targets, and triggering apoptosis in breast cancer cells. MIR96-IN-1 binds to RNAs with Kds of 1.3, 9.4, 3.4, 1.3 and 7.4 μM for RNA1, RNA2, RNA3, RNA4 and RNA5, respectively

产品描述: MIR96-IN-1 targets the Drosha site in the miR-96 (miRNA-96, microRNA-96) hairpin precursor, inhibiting its biogenesis, derepressing downstream targets, and triggering apoptosis in breast cancer cells. MIR96-IN-1 binds to RNAs with Kds of 1.3, 9.4, 3.4, 1.3 and 7.4 μM for RNA1, RNA2, RNA3, RNA4 and RNA5, respectively
靶点: MicroRNA;Apoptosis;MALT
体外研究: MIR96-IN-1 (Compound 1) selectively inhibits production of mature miR-96 and triggers apoptosis in breast cancer cells at micromolar concentrations. MIR96-IN-1 (Compound 3) binds a UU loop in miR-96 and inhibits its biogenesis
参考文献: 1. Sai Pradeep Velagapudi,et al. Design of a small molecule against an oncogenic noncoding RNA. Proc Natl Acad Sci U S A. 2016 May 24;113(21):5898-903. 2. Christopher L Haga, et al. Small Molecule Inhibition of miR-544 Biogenesis Disrupts Adaptive Responses to Hypoxia by Modulating ATM-mTOR Signaling. ACS Chem Biol. 2015 Oct 16;10(10):2267-76.
溶解性: soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 1.698 ml 8.492 ml 16.984 ml
5 mM 0.34 ml 1.698 ml 3.397 ml
10 mM 0.17 ml 0.849 ml 1.698 ml
50 mM 0.034 ml 0.17 ml 0.34 ml
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参考文献

质检证书(COA)

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摩尔浓度计算器

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