| 产品描述： | Methicillin sodium salt (Meticillin sodium) is a β-lactam, semi-synthetic antibiotic related to penicillin antibiotic. Methicillin sodium salt inhibits penicillin-binding proteins involved in the synthesis of peptidoglycan. Methicillin sodium salt inhibits S. aureus with a MIC value of 2.1 μg/mL. Methicillin sodium salt can be used for the research of inflammation |
| 靶点： |
β-lactam;Antibacterial; Antibiotic |
| 体内研究： |
Methicillin sodium salt (42.5 and 85 mg/kg; i.m. four times daily; for 21 days or till spontaneous death) against the enterococcus in leukocytes. Methicillin sodium salt (400 mg/kg; i.p. once) survives infected mice better than compared group. Methicillin sodium salt (400 mg/kg; i.h. once) prevents infected mice from death |
| 参考文献： |
1. Lincoln LJ, et al. Penicillinase-resistant penicillins plus gentamicin in experimental enterococcal endocarditis. Antimicrob Agents Chemother. 1977 Oct;12(4):484-9. 2. Mandell GL, Vest TK. Killing of intraleukocytic Staphylococcus aureus by rifampin: in-vitro and in-vivo studies. J Infect Dis. 1972 May;125(5):486-90. |
| 溶解性： |
DMSO : 125 mg/mL (310.64 mM; Need ultrasonic) H2O : 100 mg/mL (248.51 mM; Need ultrasonic) |
| 保存条件： |
2-8℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.485 ml |
12.425 ml |
24.851 ml |
| 5 mM |
0.497 ml |
2.485 ml |
4.97 ml |
| 10 mM |
0.249 ml |
1.243 ml |
2.485 ml |
| 50 mM |
0.05 ml |
0.249 ml |
0.497 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京