Vaborbactam

99.25%

Vaborbactam

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品牌：源叶(MedMol)

产品编号：S82984 一键复制产品信息

CAS号：1360457-46-0

分子式：C₁₂H₁₆BNO₅S

分子量：297.1351

别名：(3R,6S)-[2-hydroxy-3-(2-thiophen-2-ylacetylamino)[1,2]oxaborinan-6-yl]acetic acid; 2-((3R,6S)-2-hydroxy-3-(2-(thiophen-2-yl)acetamido)-1,2-oxaborinan-6-yl)acetic acid; RPX7009;

货号	规格	价格	上海	北京	珠海	重庆	武汉
S82984-1mg	99.25%	￥820.00 S82984-1mg ￥820.00 现货	4 4	-	-	-	-
S82984-5mg	99.25%	￥2620.00 S82984-5mg ￥2620.00 现货	11 >10	-	-	-	-
S82984-10mg	99.25%	￥3750.00 S82984-10mg ￥3750.00 现货	7 7	-	-	-	-

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产品介绍参考文献质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

Vaborbactam (RPX7009) is a cyclic boronic acid pharmacophore β-lactamase inhibitor.

靶点：

Bacterial;Antibacterial

体外研究：

Vaborbactam is a broad spectrum of inhibition of β-lactamases, with particularly potent activity against KPC, CTX-M, SHV, and CMY enzymes. Vaborbactam restores SM 7338 activity for 72.7 to 98.1% of CPE isolates at ≤2 μg/mL, and maximum potentiation is achieved with fixed concentrations of ≥8 μg/mL of the inhibitor (≥96.5% of isolates are inhibited at ≤2 μg/mL of SM 7338-vaborbactam). SM 7338-vaborbactam with a fixed concentration of 8 μg/mL of the inhibitor (MIC50, ≤0.06 μg/mL for all organisms) inhibits 93.7% of the CPE isolates displaying elevated SM 7338 MICs at ≤1 μg/mL. By forming a reversible dative bond with the blactamase, vaborbactam acts as a competitive inhibitor and is not hydrolyzed by the b-lactamase

体内研究：

Vaborbactam is well tolerated and has a half-life of 1.23 h, and steadystate volume of distribution of 21.0 L in subjects

参考文献：

1. Hecker SJ, et al. Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. J Med Chem. 2015 May 14;58(9):3682-92. 2. Castanheira M, et al. Effect of the β-Lactamase Inhibitor Vaborbactam Combined with SM 7338 against Serine Carbapenemase-Producing Enterobacteriaceae. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5454-8. 3. Wong D, et al. Novel Beta-Lactamase Inhibitors: Unlocking Their Potential in Therapy. Drugs. 2017 Apr;77(6):615-628.

溶解性：

Soluble in H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.365 ml	16.827 ml	33.655 ml
5 mM	0.673 ml	3.365 ml	6.731 ml
10 mM	0.337 ml	1.683 ml	3.365 ml
50 mM	0.067 ml	0.337 ml	0.673 ml