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• 产品描述： Xanomeline oxalate (LY246708 oxalate) is a potent and selective muscarinic receptor agonist (SMRA) and stimulates phosphoinositide hydrolysis in vivo. Xanomeline oxalate can be used for the research of Alzheimer’s disease

• 靶点： muscarinic receptor;AChR

• 体外研究：
  Xanomeline stimulates phosphoinositide (PI) hydrolysis in the A9 L m1 cells. Xanomeline inhibits [3H]-pirenzepine ([3H]-PZ) and [3H]-oxotremorine-M ([3H]-OXO-M) binding to rat brain with Kis of 7 and 3 nM, respectively

• 体内研究：
  Xanomeline robustly stimulates in vivo PI hydrolysis and the effect is blocked by muscarinic antagonists, demonstrating mediation by muscarinic receptors. In mice the ED100 for Xanomeline-induced stimulation of [3H]-IP accumulation is 54 μmole/kg in hippocampus. And in rats the ED100 for Xanomeline-induced stimulation of [3H]-IP accumulation is 8.1 μmole/kg in hippocampus. Animal Model: Male CF1 mice weighing 18-20 g are injected [3H]-myoinositol Dosage: 8.1-81 μmole/kg Administration: S.c. injections; 1 h prior to killing and 1 h after the administration Result: Increased accumulation in a dose-related manner up to 130%, 75%, 60% above lithium levels in hippocampus, cortex and neostriatum, respectively. And did not increase accumulation of [3H]-IP in the brain stem. Induced salivation, tremor and hypothermia in mice with the ED50 of 13.7±0.8 μmole/kg. Animal Model: Rats are injected [3H]-myoinositol Dosage: 2.7-81 μmole/kg Administration: S.c. injections; 1 h prior to killing and 1 h after the administration Result: Increased [3H]-IP formation dose dependently in hippocampus up to 221% above lithium control.

• 参考文献：
  1. F P Bymaster, et al. Xanomeline Compared to Other Muscarinic Agents on Stimulation of Phosphoinositide Hydrolysis in Vivo and Other Cholinomimetic Effects. Brain Res. 1998 Jun 8; 795(1-2):179-90.

• 溶解性： soluble  in  DMSO

• 保存条件： 2-8℃;充氩;干燥

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.692 ml	13.461 ml	26.921 ml
  5 mM	0.538 ml	2.692 ml	5.384 ml
  10 mM	0.269 ml	1.346 ml	2.692 ml
  50 mM	0.054 ml	0.269 ml	0.538 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *