| 产品描述： | PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor with an IC50 of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC50s of 152 nM and 1046 nM, respectively. |
| 靶点： |
PI4KIIIβ:7 nM (IC50);PI4KIIIα:2.6 μM (IC50);PI3Kδ:152 nM (IC50);PI3Kγ:1046 nM (IC50);PI3Kα:2 μM (IC50);PI3KC2γ:1 μM (IC50);PI3K; PI4K |
| 体外研究： |
PI4KIIIbeta-IN-9 (Compound 9) shows weak inhibition of PI3KC2γ (IC50 ~1 µM), PI3Kα (~2 µM), and PI4KIIIα (~2.6 µM) and <50% inhibition at concentrations up to 20 µM for PI4K2α, PI4K2β, and PI3Kβ. PI4KIIIbeta-IN-9 (Compound 9) forms a crescent shape that conforms to the active site of PI4KIIIβ. This molecule makes extensive contacts with PI4KIIIβ |
| 参考文献： |
1. Rutaganira FU, et al. Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ. J Med Chem. 2016 Mar 10;59(5):1830-9. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.051 ml |
10.254 ml |
20.509 ml |
| 5 mM |
0.41 ml |
2.051 ml |
4.102 ml |
| 10 mM |
0.205 ml |
1.025 ml |
2.051 ml |
| 50 mM |
0.041 ml |
0.205 ml |
0.41 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京