ALS-8176

    
98%

ALS-8176

源叶(MedMol)
S83356 一键复制产品信息
1445385-02-3
C18H25ClFN3O6
433.859
货号 规格 价格 上海 北京 武汉 南京 购买数量
S83356-1mg 98% ¥1500.00 货期:2-3天 - - -
S83356-5mg 98% ¥3500.00 货期:2-3天 - - -
S83356-10mg 98% ¥5000.00 货期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Lumicitabine (ALS-008176) is an inhibitor of the respiratory syncytial virus (RSV) polymerase.

产品描述: Lumicitabine (ALS-008176) is an inhibitor of the respiratory syncytial virus (RSV) polymerase.
靶点: RSV
体外研究: Lumicitabine is an orally bioavailable prodrug of the novel RSV replication inhibitor ALS-008112, a cytidine nucleoside analogue
体内研究: Lumicitabine demonstrates excellent anti-RSV efficacy and safety in a phase 2 clinical RSV challenge study. It exhibits good oral bioavailability and a high level of 2c-TP in vivo. Lumicitabine has excellent stability profiles in formulations (>24 h storage stability in 0.5% methylcellulose aqueous formulation at rt) and simulats gastric and intestinal fluids (half-life >2 h). Its solubility is adequate to support oral administration in solutions with relatively low percentage of organic solvent and in aqueous suspensions. High levels of NMP and NTP are obtained following oral administration of Lumicitabine to monkeys. In an adult human challenge study, Lumicitabine has shown efficacy against RSV infection
参考文献: 1. DeVincenzo JP, et al. Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study. N Engl J Med. 2015 Nov 19;373(21):2048-58. 2. Wang G, et al. Discovery of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection. J Med Chem. 2015 Feb 26;58(4):1862-78.
溶解性: soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.305 ml 11.524 ml 23.049 ml
5 mM 0.461 ml 2.305 ml 4.61 ml
10 mM 0.23 ml 1.152 ml 2.305 ml
50 mM 0.046 ml 0.23 ml 0.461 ml
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参考文献

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摩尔浓度计算器

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