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Lu AF21934

源叶(MedMol) 98%
  • 英文名:
  • Lu AF21934
  • 别名:
  • CAS号:
  • 1445605-23-1
  • 分子式:
  • C14H16Cl2N2O2
  • 分子量:
  • 315.195
  • 核磁/质谱:
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S83360-2mg 98% ¥340.00元 5 - - - EA 加入购物车
源叶(MedMol) S83360-5mg 98% ¥629.00元 4 - - - EA 加入购物车
源叶(MedMol) S83360-10mg 98% ¥1062.50元 5 - - - EA 加入购物车
源叶(MedMol) S83360-25mg 98% ¥2210.00元 6 - - - EA 加入购物车
源叶(MedMol) S83360-50mg 98% ¥3655.00元 预计交期:2-3天 - - - EA 加入购物车
源叶(MedMol) S83360-100mg 98% ¥5600.00元 预计交期:2-3天 - - - EA 加入购物车
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  • 提示:详情请下载说明书。
  • 产品描述: Lu AF21934 is a selective and brain-penetrant mGlu4 receptor positive allosteric modulator with an EC50 of 500 nM for mGlu4 receptor
  • 靶点: mGlu4 Receptor:500 nM (EC50);GluR
  • 体内研究:
    Lu AF21934 treatment shows a dose-dependent anxiolytic-like effect in the stress-induced hyperthermia, four-plate, and marble-burying tests. The anti-hyperthermic effect of Lu AF21934 (5 mg/kg) in the SIH test is inhibited by the benzodiazepine receptor antagonist flumazenil (10 mg/kg) and is not serotonin dependent. Lu AF21934 does not produce antidepressant-like effects in the tail suspension test in mice; however, it decreases the basal locomotor activity of mice that are not habituated to activity cages. Lu AF21934 (0.5-5 mg/kg sc) does not influence tremor but at doses of 0.5 and 2.5 mg/kg reverses harmaline-induced hyperactivity. Lu AF21934 at a dose of 2.5 mg/kg potentiates the inhibitory influence of harmaline on the exploratory activity and AP1 during the first 30 min of the measurement and counteracts the harmaline-increased basic activity during the period of 30-90 min. Lu AF21934 (0.1-5 mg/kg) dose-dependently inhibits hyperactivity induced by MK-801 or amphetamine. It also antagonizes head twitches and increases frequency of spontaneous excitatory postsynaptic currents in brain slices, induced by DOI
  • 参考文献:
    1. Anna Sławińska, et al. Anxiolytic- but not antidepressant-like activity of Lu AF21934, a novel, selective positive allosteric modulator of the mGlu? receptor. Neuropharmacology. 2013 Mar;66:225-35. 2. Ossowska K, et al. Lu AF21934, a positive allosteric modulator of mGlu4 receptors, reduces the harmaline-induced hyperactivity but not tremor in rats. Neuropharmacology. 2014 Aug;83:28-35. 3. Anna Sławińska, et al. The antipsychotic-like effects of positive allosteric modulators of metabotropic glutamate mGlu4 receptors in rodents. Br J Pharmacol. 2013 Aug;169(8):1824-39.
  • 溶解性: Soluble  in  DMSO
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 3.173 ml 15.863 ml 31.726 ml
    5 mM 0.635 ml 3.173 ml 6.345 ml
    10 mM 0.317 ml 1.586 ml 3.173 ml
    50 mM 0.063 ml 0.317 ml 0.635 ml
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