| 品牌 | 货号 | 产品规格 | 价格(RMB) | 库存（上海） | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
| 源叶(MedMol) | S83417-1mg | 98% | ￥552.50元 | 10 | - | - | - |
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| 源叶(MedMol) | S83417-5mg | 98% | ￥765.00元 | 10 | - | - | - |
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| 源叶(MedMol) | S83417-10mg | 98% | ￥1232.50元 | 9 | - | - | - |
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| 源叶(MedMol) | S83417-50mg | 98% | ￥3200.00元 | 7 | - | - | - |
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| 产品描述： GJ103 sodium salt is an active analog of GJ072, a read-through compound. | ||||||||||||||||||||
| 靶点： ATM/ATR | ||||||||||||||||||||
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体外研究： GJ072 induces ATM kinase on both TGA and TAG stop codons and restored ATMpSer1981 autophosphorylation and SMC1pSer966 transphosphorylation as measured by FACS. GJ072 is active in A-T cells with a homozygous TAA mutation. GJ072 is able to induce detectable full-length ATM protein in treated A-T cells. Early structure-activity relationship studies generates eight active analogs of GJ072. Some GJ072 analogs (e.g., GJ103, GJ106, GJ109, and GJ111) consistently demonstrates their activities in all three PTCs by both FCATMpSer1981 and IRIF assays. GJ071 and GJ072 and some of their analogs (such as GJ103) have similar read-through activity as RTC13 or RTC14, but are more tolerable than RTC13 and RTC14 to A-T cells. GJ103 does not show obvious cytotoxicity in A-T cells at concentration as high as 300 μM. |
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体内研究： GJ103 sodium salt is water soluble, which will enable us to evaluate its in vivo activity by systematic administration. |
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参考文献： 1. Du L, et al. A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene. Mol Ther. 2013 Sep;21(9):1653-60. |
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| 溶解性： Soluble in DMSO | ||||||||||||||||||||
| 保存条件： -20℃ | ||||||||||||||||||||
配置溶液浓度参考：
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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