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S83420

BM212

源叶(MedMol) 99%
  • 英文名:
  • BM212
  • 别名:
  • UNII-U9HSU4GZWL; BM212;
  • CAS号:
  • 146204-42-4
  • 分子式:
  • C23H25Cl2N3
  • 分子量:
  • 414.3707
  • 核磁/质谱:
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S83420-1mg 99% ¥495.00元 10 - - - EA 加入购物车
源叶(MedMol) S83420-5mg 99% ¥1230.00元 5 - - - EA 加入购物车
源叶(MedMol) S83420-10mg 99% ¥1730.00元 5 - - - EA 加入购物车
源叶(MedMol) S83420-50mg 99% ¥3800.00元 2 - - - EA 加入购物车
源叶(MedMol) S83420-100mg 99% ¥5200.00元 预计交期:2-3天 - - - EA 加入购物车
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  • 提示:详情请下载说明书。
  • 产品描述: BM212 is a potent Mycobacterial membrane protein Large 3 (MmpL3) inhibitor. BM212 has strong bactericidal activity against both M. tuberculosis and some nontuberculosis mycobacteria. BM212 exhibits antimycobacterial activity against M. tuberculosis H37Rv with an MIC of 5 µM
  • 靶点: M. tuberculosis;Antibacterial
  • 体外研究:
    BM212 (2 μg/mL and 8 μg/mL) leads to major structural changes in the cell of M. abscessus CIP104536T S and R variants and results in the complete loss of the hydrophobic nanodomains observed on S cells but no significantly affect on R cells at dose of 2 μg/mL. BM212 (0.5-10 μg/mL, 7 days) inhibits the activity of Mycobacterium avium in U937 cells in a dose-dependent manner with a MIC of 0.5 μg/mL and 100% inhibition starting at a concentration of 1 μg/mL
  • 参考文献:
    1. Deidda D et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Nov;42(11):3035-7. 2. Poce G et al. Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection. PLoS One. 2013;8(2) 3. Albertus Viljoen, et al. Fast chemical force microscopy demonstrates that glycopeptidolipids define nanodomains of varying hydrophobicity on mycobacteria. Nanoscale Horiz. 2020 Jun 1;5(6):944-953. 4. Delia Deidda, et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Nov;42(11):3035-7.
  • 溶解性: Soluble  in  DMSO、Ethanol
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 2.413 ml 12.066 ml 24.133 ml
    5 mM 0.483 ml 2.413 ml 4.827 ml
    10 mM 0.241 ml 1.207 ml 2.413 ml
    50 mM 0.048 ml 0.241 ml 0.483 ml
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