| 产品描述： | Trovirdine inhibits HIV-1 RT with an IC50 of 7 nM when employing heteropolymeric primer/template (oligo-DNA/ribosomal RNA)and dGTP as substrate. IC50 value: 7 nM Target: HIV-1 Trovirdine is currently in phase I clinical trials for potential use in thetreatment of AIDS. |
| 靶点： |
HIV;HIVProtease |
| 参考文献： |
1. Zhang, H. et al. Inhibition of human immunodeficiency virus type 1 wild-type and mutant reverse transcriptases by the phenyl ethylthiazolyl thiourea derivatives trovirdine and MSC-127. 2. Cantrell, A.S. et al. Phenethylthiazolylthiourea (PETT) compounds as a newclass of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs. |
| 溶解性： |
DMSO : 100 mg/mL (296.52 mM; Need ultrasonic) |
| 保存条件： |
2-8℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.965 ml |
14.826 ml |
29.653 ml |
| 5 mM |
0.593 ml |
2.965 ml |
5.931 ml |
| 10 mM |
0.297 ml |
1.483 ml |
2.965 ml |
| 50 mM |
0.059 ml |
0.297 ml |
0.593 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京