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S83597

CWHM-12

源叶(MedMol) 98%
  • 英文名:
  • CWHM-12
  • 别名:
  • 5; 4; (2S)-2-(3-bromo-5-(tert-butyl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1; 6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid;
  • CAS号:
  • 1564286-55-0
  • 分子式:
  • C26H32BrN5O6
  • 分子量:
  • 590.4662
  • 核磁/质谱:
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S83597-2mg 98% ¥612.00元 10 - - - EA 加入购物车
源叶(MedMol) S83597-5mg 98% ¥918.00元 >10 - - - EA 加入购物车
源叶(MedMol) S83597-10mg 98% ¥1496.00元 >10 - - - EA 加入购物车
源叶(MedMol) S83597-50mg 98% ¥4300.00元 预计交期:2-3天 - - - EA 加入购物车
源叶(MedMol) S83597-100mg 98% ¥6200.00元 预计交期:2-3天 - - - EA 加入购物车
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参考文献

质检证书(COA)

摩尔浓度计算器

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  • 提示:详情请下载说明书。
  • 产品描述: CWHM-12 is a potent inhibitor of αV integrins with IC50s of 0.2, 0.8, 1.5, and 1.8 nM for αvβ8, αvβ3, αvβ6, and αvβ1.
  • 靶点: IC50: 0.2 nM (αvβ8), 0.8 nM (αvβ3), 1.5 nM (αvβ6), 1.8 nM (αvβ1), 61 nM (αvβ5);Integrin
  • 体外研究:
    CWHM-12 (CWHM 12) also less potently inhibits αvβ5 (IC50=61 nM) and αIIbβ3/α2β1/α10β1 (IC50>5000 nM). CWHM-12 demonstrates high potency against all of the five possible β subunit binding partners (αvβ1, αvβ3, αvβ5, αvβ6 and αvβ8) in in vitro ligand-binding assays, with somewhat less potency against αvβ5 than against the other αv integrins
  • 体内研究:
    Mice are treated with CCl4 for 3 weeks to establish fibrotic disease and then treated with CWHM-12 (CWHM 12) or vehicle for the final 3 weeks of CCl4. CWHM-12 significantly reduces liver fibrosis even after fibrotic disease have been established. Digital image quantitation demonstrates significantly reduced p-SMAD3 signaling in the livers of CWHM-12 treated mice compare to controls, demonstrating that the protection from CCl4-induced hepatic fibrosis observed in CWHM-12 treated mice is due at least in part to a reduction in TGF-β activation by αv integrins. Besides, administration of CWHM-12 significantly inhibited progression of pulmonary fibrosis
  • 参考文献:
    1. Henderson NC, et al. Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013 Dec;19(12):1617-24. 2. Basta J, Robbins L, Stout L, Prinsen MJ, Griggs DW, Rauchman M. Pharmacologic inhibition of RGD-binding integrins ameliorates fibrosis and improves function following kidney injury. Physiol Rep. 2020;8(7):e14329
  • 溶解性: Soluble  in  DMSO
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 1.694 ml 8.468 ml 16.936 ml
    5 mM 0.339 ml 1.694 ml 3.387 ml
    10 mM 0.169 ml 0.847 ml 1.694 ml
    50 mM 0.034 ml 0.169 ml 0.339 ml
  • 注意:部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)


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