| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S83671-2mg |
≥98% | ￥770.00 | 货期：2-3天 | - | - | - |
|
S83671-5mg |
≥98% | ￥1110.00 | 货期：2-3天 | - | - | - |
|
S83671-10mg |
≥98% | ￥1950.00 | 货期：2-3天 | - | - | - |
|
S83671-25mg |
≥98% | ￥3900.00 | 货期：2-3天 | - | - | - |
|
S83671-50mg |
≥98% | ￥6200.00 | 货期：2-3天 | - | - | - |
|
S83671-100mg |
≥98% | ￥10500.00 | 货期：2-3天 | - | - | - |
|
GPR120 Agonist 3 is a selective Gpr120 agonist with a logEC50 of −7.62.
| 产品描述： | GPR120 Agonist 3 is a selective Gpr120 agonist with a logEC50 of −7.62. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | logEC50: −7.62;GPR | ||||||||||||||||||||
| 体外研究： | GPR120 Agonist 3 is fully selective for Gpr120 (logEC50=−7.62) with negligible activity towards Gpr40. GPR120 Agonist 3 produces concentration dependent increases in IP3 production from both human and mouse Gpr120 expressing cells. GPR120 Agonist 3 leads to a concentration-dependent response to recruit β-arrestin-2 in both human and mouse Gpr120 expressing cells, with EC50s of ~0.35 μM. GPR120 Agonist 3 strongly and comparably inhibits LPS-induced phosphorylation of Tak1, Ikkβ, and Jnk and blocked IκB degradation | ||||||||||||||||||||
| 体内研究： | GPR120 Agonist 3 causes improved insulin sensitivity with increased glucose infusion rates, enhanced insulin stimulated-glucose disposal rate, along with a marked increase in the ability of insulin to suppress hepatic glucose production only in WT mice. GPR120 Agonist 3 treatment has beneficial effects on hepatic lipid metabolism, causing decreased hepatic steatosis, decreased liver triglycerides, and DAGs, along with reduced saturated free fatty acid conten | ||||||||||||||||||||
| 参考文献： | 1. Oh DY, et al. A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. Nat Med. 2014 Aug;20(8):942-7. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
|
||||||||||||||||||||
| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
沪公网安备 31011702002021号
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京