GPR120-IN-1

    
98%

GPR120-IN-1

源叶(MedMol)
S83671 一键复制产品信息
1599477-75-4
C19H23ClF3NO3
405.8390296
GPR120CompoundANEW
货号 规格 价格 上海 北京 武汉 南京 购买数量
S83671-2mg 98% ¥770.00 货期:2-3天 - - -
S83671-5mg 98% ¥1110.00 货期:2-3天 - - -
S83671-10mg 98% ¥1950.00 货期:2-3天 - - -
S83671-25mg 98% ¥3900.00 货期:2-3天 - - -
S83671-50mg 98% ¥6200.00 货期:2-3天 - - -
S83671-100mg 98% ¥10500.00 货期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

GPR120 Agonist 3 is a selective Gpr120 agonist with a logEC50 of −7.62.

产品描述: GPR120 Agonist 3 is a selective Gpr120 agonist with a logEC50 of −7.62.
靶点: logEC50: −7.62;GPR
体外研究: GPR120 Agonist 3 is fully selective for Gpr120 (logEC50=−7.62) with negligible activity towards Gpr40. GPR120 Agonist 3 produces concentration dependent increases in IP3 production from both human and mouse Gpr120 expressing cells. GPR120 Agonist 3 leads to a concentration-dependent response to recruit β-arrestin-2 in both human and mouse Gpr120 expressing cells, with EC50s of ~0.35 μM. GPR120 Agonist 3 strongly and comparably inhibits LPS-induced phosphorylation of Tak1, Ikkβ, and Jnk and blocked IκB degradation
体内研究: GPR120 Agonist 3 causes improved insulin sensitivity with increased glucose infusion rates, enhanced insulin stimulated-glucose disposal rate, along with a marked increase in the ability of insulin to suppress hepatic glucose production only in WT mice. GPR120 Agonist 3 treatment has beneficial effects on hepatic lipid metabolism, causing decreased hepatic steatosis, decreased liver triglycerides, and DAGs, along with reduced saturated free fatty acid conten
参考文献: 1. Oh DY, et al. A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. Nat Med. 2014 Aug;20(8):942-7.
溶解性: soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.464 ml 12.32 ml 24.64 ml
5 mM 0.493 ml 2.464 ml 4.928 ml
10 mM 0.246 ml 1.232 ml 2.464 ml
50 mM 0.049 ml 0.246 ml 0.493 ml
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参考文献

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摩尔浓度计算器

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