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Adelmidrol 98%

Adelmidrol

源叶(MedMol)
S83855
1675-66-7
C13H26N2O4
274.3565
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S83855-5mg 98% ¥112.00元 10 - - -
源叶(MedMol) S83855-25mg 98% ¥208.00元 10 - - -
源叶(MedMol) S83855-100mg 98% ¥392.00元 7 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Adelmidrol exerts important anti-inflammatory effects that are partly dependent on PPARγ. Adelmidrol reduces NF-κB translocation, and COX-2 expression.
产品描述: Adelmidrol exerts important anti-inflammatory effects that are partly dependent on PPARγ. Adelmidrol reduces NF-κB translocation, and COX-2 expression.
靶点: NF-κB;COX-2;PPARγ;NF-κB; COX; PPAR
体外研究:
Adelmidrol is a palmitoylethanolamide analogue. Adelmidrol reduces NF-κB translocation, COX-2, and p-ERK expression; proinflammatory cytokine release; and the incidence of nitrotyrosine and poly(ADP)ribose in the colo
体内研究:
Adelmidrol (10 mg/kg, o.s.) reduces significantly the degree and severity of the macroscopic and histologic signs of colon injury. Moreover, 4 days after colitis induced by dinitrobenzene sulfonic acid (DNBS) treatment, all mice have diarrhea and a reduction in body weight (compared with the sham groups). Adelmidrol (10 mg/kg, o.s.) treatment significantly reduces the loss of body weight. The inflammatory bowel disease (IBD) induced by DNBS intrarectally administered is also characterized by an augmentation in myeloperoxidase (MPO) activity, an indicator of neutrophil accumulating in the colon. This is consistent with light microscopic observations showing the colon of vehicle-treated DNBS mice to contain a large number of neutrophils. In contrast, Adelmidrol (10 mg/kg, o.s.) significantly reduces the degree of polymorphonuclear cell infiltration (determined as reduction in MPO activity) in inflamed colon
参考文献:
1. Cordaro M, et al. Adelmidrol, a Palmitoylethanolamide Analogue, as a New Pharmacological Treatment for the Management of Inflammatory Bowel Disease. Mol Pharmacol. 2016 Nov;90(5):549-561.
溶解性: Soluble  in  DMSO、H2O
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 3.645 ml 18.224 ml 36.449 ml
5 mM 0.729 ml 3.645 ml 7.29 ml
10 mM 0.364 ml 1.822 ml 3.645 ml
50 mM 0.073 ml 0.364 ml 0.729 ml
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参考文献

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摩尔浓度计算器

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