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Ro 25-6981 98%

(AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE

源叶(MedMol)
S83871
169274-78-6
C26H33NO6
455.543
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S83871-5mg 98% ¥990.00元 预计交期:2-3天 - - -
源叶(MedMol) S83871-10mg 98% ¥1380.00元 预计交期:2-3天 - - -
源叶(MedMol) S83871-50mg 98% ¥4900.00元 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Ro 25-6981 is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 has the potential for the research of parkinson's disease (PD)
产品描述: Ro 25-6981 is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 has the potential for the research of parkinson's disease (PD)
靶点: NMDA Receptor;NMDAR
体内研究:
Ro 25-6981 (0.39-12.5 mg/kg; i.p.) induces contraversive rotations in 6-hydroxydopamine (6-OHDA)-lesioned rats without stimulating locomotion in normal rats. Ro 25-6981 (1,3 mg/kg; i.p.) exhibits age- and activation-dependent anticonvulsant action at early postnatal development in rats. Ro 25-6981 (800 µg; intrathecal injection) shows significant analgesic effects on incision pain in rats and effectively attenuated postoperative hyperalgesia
参考文献:
1. Löschmann PA, et al. Antiparkinsonian activity of Ro 25-6981, a NR2B subunit specific NMDA receptor antagonist, in animal models of Parkinson's disease. Exp Neurol. 2004 May;187(1):86-93. 2. Szczurowska E,et al. Different action of a specific NR2B/NMDA antagonist Ro 25-6981 on cortical evoked potentials and epileptic afterdischarges in immature rats. Brain Res Bull. 2015 Feb;111:1-8. 3. Jiang M, et al. Antinociception and prevention of hyperalgesia by intrathecal administration of Ro 25-6981, a highly selective antagonist of the 2B subunit of N-methyl-D-aspartate receptor. Pharmacol Biochem Behav. 2013 Nov;112:56-63.
溶解性: Soluble  in  DMSO
保存条件: RT
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.195 ml 10.976 ml 21.952 ml
5 mM 0.439 ml 2.195 ml 4.39 ml
10 mM 0.22 ml 1.098 ml 2.195 ml
50 mM 0.044 ml 0.22 ml 0.439 ml
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参考文献

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摩尔浓度计算器

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