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S83897

E4CPG

源叶(MedMol) 98%
  • 英文名:
  • E4CPG
  • 别名:
  • CAS号:
  • 170846-89-6
  • 分子式:
  • C11H13NO4
  • 分子量:
  • 223.2252
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S83897-5mg 98% ¥750.00元 预计交期:2-3天 - - - EA 加入购物车
源叶(MedMol) S83897-10mg 98% ¥1000.00元 预计交期:2-3天 - - - EA 加入购物车
源叶(MedMol) S83897-25mg 98% ¥2200.00元 预计交期:2-3天 - - - EA 加入购物车
源叶(MedMol) S83897-50mg 98% ¥3900.00元 预计交期:2-3天 - - - EA 加入购物车
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  • 产品描述: E4CPG ((RS)-ECPG) is a Group I/Group II metabotropic glutamate receptor (mGluR) antagonist. E4CPG can inhibit the paired-pulse ratio of monosynaptic inhibitory postsynaptic currents (IPSC) potentiation
  • 靶点: mGluR;GluR
  • 体外研究:
    E4CPG acts at rat cortical mGluR with the KB value of 0.367 mM
  • 体内研究:
    E4CPG (3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.), and 1-10 nmol/site (i.c.v.)) significantly inhibits the nociception induced by the Glutamate-injection (i.pl.; 30 μmol/paw), and the maximal inhibition values for the antinociceptive action of E4CPG in Glutamate-induced nociception are 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.). E4CPG (35 nM/3.5 μL, i.c.v.) completely blocks long-term depression (LTD) induced by the group I mGluR agonist Dihydroxyphenylglycine (DHPG, 100 nM/5 μL, i.c.v.) in male Sprague-Dawley rats. Animal Model: Male Swiss mice (25-35 g) Dosage: 3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.) and 1-10 nmol/ site (i.c.v.) Administration: Single injection Result: The maximal inhibition values for the antinociceptive action of E4CPG in glutamate-induced nociception were 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.). Animal Model: Male Sprague-Dawley rats Dosage: 35 nM/3.5 μL Administration: Single injection, i.c.v. Result: Completely blocked LTD induced by the group I mGluR agonist dihydroxyphenylglycine (DHPG).
  • 参考文献:
    1. N Sekiyama, et al. Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptorsubtypes. Br J Pharmacol, 1996 Apr, 117(7):1493-503. 2. Christian Patenaude, et al. GABAB receptor- and metabotropic glutamate receptor-dependent cooperative long-term potentiation of rat hippocampal GABAA synaptic transmission. J Physiol. 2003 Nov 15;553(Pt 1):155-67. 3. J S Bedingfield, et al. Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs). Br J Pharmacol. 1995 Dec;116(8):3323-9. 4. Alessandra Beirith, et al. Mechanisms underlying the nociception and paw oedema caused by injection of glutamate into the mouse paw. Brain Res. 2002 Jan 11;924(2):219-28. 5. Jing Han, et al. Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD. Cell. 2012 Mar 2;148(5):1039-50.
  • 溶解性: Soluble  in  DMSO、H2O
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 4.48 ml 22.399 ml 44.798 ml
    5 mM 0.896 ml 4.48 ml 8.96 ml
    10 mM 0.448 ml 2.24 ml 4.48 ml
    50 mM 0.09 ml 0.448 ml 0.896 ml
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