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S83943

Tipranavir

源叶(MedMol) 99%
  • 英文名:
  • Tipranavir
  • 别名:
  • N-[3-[(1R)-1-[(6R)-2-羟基-4-氧代-6-苯乙基-6-丙基-5H-吡喃-3-基]丙基]苯基]-5-(三氟甲基)吡啶-2-磺酰胺;Aptivus; 2o4l; Tipranavir; 1d4y; UNII-ZZT404XD09; N-[3-[(1R)-1-[(2R)-4-hydroxy-6-oxo-2-(2-phenylethyl)-2-propyl-3H-pyran-5-yl]
  • CAS号:
  • 174484-41-4
  • 分子式:
  • C31H33F3N2O5S
  • 分子量:
  • 602.66
  • 核磁/质谱:
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S83943-1mg 99% ¥807.50元 4 - - - EA 加入购物车
源叶(MedMol) S83943-5mg 99% ¥2380.00元 8 - - - EA 加入购物车
源叶(MedMol) S83943-10mg 99% ¥3100.00元 7 - - - EA 加入购物车
源叶(MedMol) S83943-25mg 99% ¥5300.00元 6 - - - EA 加入购物车
源叶(MedMol) S83943-50mg 99% ¥9100.00元 6 - - - EA 加入购物车
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  • 提示:详情请下载说明书。
  • 产品描述: Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates with IC50s of 66-410 nM. Tipranavir inhibits SARS-CoV-2 3CLpro activity
  • 靶点: IC50: 66-410 nM (HIV-1 isolates);SARS-CoV; HIVProtease
  • 体内研究:
    Tipranavir (PNU-140690) is administered orally twice daily and must be given in combination with low-dose ritonavir (RTV) to boost Tipranavir bioavailability. In Tipranavir/r-cotreated mice, the Tipranavir (PNU-140690) abundance in the liver, spleen, and eyes is significantly higher than that in mice treated with Tipranavir alone. Tipranavir (PNU-140690) metabolites accounts for 31 and 38% in the serum and liver in the Tipranavir-alone group. In Tipranavir (PNU-140690) and Tipranavir (TPV/r)-cotreated mice, only 1 and 2% of metabolites are detected in the serum and liver. Sprague-Dawley rats are administered a single dose of [14C]Tipranavir (PNU-140690) with coadministration of RTV. The most abundant metabolite in feces is an oxidation metabolite. In urine, no single metabolite is found to be significantly present
  • 参考文献:
    1. Aoki M, et al. Loss of the protease dimerization inhibition activity of tipranavir (TPV) and its association with the acquisition of resistance to TPV by HIV-1. J Virol. 2012 Dec;86(24):13384-96. 2. Li F, et al. Metabolism-mediated drug interactions associated with ritonavir-boosted tipranavir in mice. Drug Metab Dispos. 2010 May;38(5):871-8. 3. Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212.
  • 溶解性: Soluble  in  DMSO、Ethanol
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 1.659 ml 8.297 ml 16.593 ml
    5 mM 0.332 ml 1.659 ml 3.319 ml
    10 mM 0.166 ml 0.83 ml 1.659 ml
    50 mM 0.033 ml 0.166 ml 0.332 ml
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