货号	规格	价格	上海	北京	武汉	南京
S84060-1mg	99%	￥230.00 S84060-1mg ￥230.00 2-3天	0 货期：2-3天	-	-	-
S84060-5mg	99%	￥495.00 S84060-5mg ￥495.00 2-3天	0 货期：2-3天	-	-	-
S84060-10mg	99%	￥740.00 S84060-10mg ￥740.00 2-3天	0 货期：2-3天	-	-	-
S84060-25mg	99%	￥1820.00 S84060-25mg ￥1820.00 2-3天	0 货期：2-3天	-	-	-

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产品介绍

Ravuconazole (BMS-207147;ER-30346) is an orally available triazole antifungle agent that potently inhibits a wide range of fungi.

产品描述：

Ravuconazole (BMS-207147;ER-30346) is an orally available triazole antifungle agent that potently inhibits a wide range of fungi.

靶点：

Fungal;Antifungal

体内研究：

The maximum concentration of ravuconazole in plasma and the area under the concentration-time curve for ravuconazoleshow good linearity over a range of doses from 2 to 40 mg/kg of body weight. Ravuconazole at a dose of 2.5 mg/kg delays mortality significantly compared with the control treatment.Ravuconazole also shows a substantial therapeutic effect against systemic cryptococcosis. Ravuconazole reduces the numbers of CFU in the lungs significantly compared with the numbers of CFU in the lungs of the controls. In an experimental model of oral candidiasis in rats, ravuconazole reduces the numbers of CFU in oral swabs significantly compared with the numbers of CFU in oral swabs from the controls and is more effective than itraconazole and as effective as fluconazole.

参考文献：

1. Hata K, et al. In vitro and in vivo antifungal activities of ER-30346, a novel oral triazole with a broad antifungal spectrum.Antimicrob Agents Chemother. 1996 Oct;40(10):2237-42. 2. Fung-Tomc JC, et al. In vitro activity of a new oral triazole, BMS-207147 (ER-30346)Antimicrob Agents Chemother. 1998 Feb;42(2):313-8. 3. Hata K, et al. Efficacy of ER-30346, a novel oral triazole antifungal agent, in experimental models of aspergillosis, candidiasis, and cryptococcosis.Antimicrob Agents Chemother. 1996 Oct;40(10):2243-7.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.286 ml	11.429 ml	22.859 ml
5 mM	0.457 ml	2.286 ml	4.572 ml
10 mM	0.229 ml	1.143 ml	2.286 ml
50 mM	0.046 ml	0.229 ml	0.457 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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分子摩尔量

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Ravuconazole (BMS-207147; ER-30346)

4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)b utan-2-yl]-1,3-thiazol-4-yl]benzonitrile