|
产品描述： LY 344864 is a selective, orally active 5-HT1F receptor agonist with a Ki of 6 nM. LY 344864 is a full agonist producing an effect similar in magnitude to serotonin itself. LY 344864 can cross the blood brain barrier to some extent |
|
靶点：
human 5-HT1F Receptor：0.006 μM (Ki)；human 5-HT1A Receptor：0.530 μM (Ki)；human 5-HT1B Receptor：0.549 μM (Ki)；human 5-HT1D Receptor：0.575 μM (Ki)；human 5-HT1E Receptor：1.415 μM (Ki)；human 5-HT2B Receptor：1.695 μM (Ki)；Human 5-HT2A Receptor：3.499 μM (Ki)；Human 5-HT3A Receptor：3.935 mM (Ki)；Human 5-HT7 Receptor：4.851 μM (Ki)；rat α2-adrenergic receptor：3.69 μM (Ki)；rat α1-adrenergic receptor：5.06 μM (Ki) |
体内研究：
LY 344864 (0-10 ng/kg; p.o. or i.v.; once) inhibits neurogenic dural inflammation in rat migraine pain model. LY 344864 (1 mg/kg; i.v.; once) can cross the blood brain barrier to some extent in rats. LY 344864 (2 mg/kg; i.p.; daily for 14 days) attenuates dopaminergic neuron loss and improved behavioral endpoints in a Parkinson’s disease mouse model |
参考文献：
1. Phebus LA, Johnson KW, Zgombick JM, Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brainpenetration and activity in the neurogenic dural inflammation model of migraine. Life Sci. 1997;61(21):2117-26. 2. Scholpa NE, et al. 5-HT1F receptor-mediated mitochondrial biogenesis for the treatment of Parkinson's disease. Br J Pharmacol. 2018 Jan;175(2):348-358. |
|
溶解性：
Soluble in DMSO |
|
保存条件：
RT |
配置溶液浓度参考：
|
1mg |
5mg |
10mg |
| 1 mM |
2.578 ml |
12.891 ml |
25.781 ml |
| 5 mM |
0.516 ml |
2.578 ml |
5.156 ml |
| 10 mM |
0.258 ml |
1.289 ml |
2.578 ml |
| 50 mM |
0.052 ml |
0.258 ml |
0.516 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京