产品描述: | BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively. |
靶点: |
Serine Protease;SerineProtease |
体外研究: |
BCX 1470 methanesulfonate is an inhibitor serine protease. BCX 1470 blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro. |
体内研究: |
BCX 1470 methanesulfonate blocked the development of RPA-induced edema in the rat. |
参考文献: |
1. Szalai AJ, Digerness SB, Agrawal A, Kearney JF, Bucy RP, Niwas S, Kilpatrick JM, Babu YS, Volanakis JE.The Arthus reaction in rodents: species-specific requirement of complement.J Immunol. 2000 Jan 1;164(1):463-8. 2. Szalai, Alexander J.; Digerness, Stanley B.; et al.; The Arthus Reaction in Rodents: Species-Specific Requirement of ComplementJournal of Immunology, 2000, 164, 463-468 |
溶解性: |
Soluble in DMSO |
保存条件: |
-20℃ |
配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
1 mM |
2.51 ml |
12.548 ml |
25.096 ml |
5 mM |
0.502 ml |
2.51 ml |
5.019 ml |
10 mM |
0.251 ml |
1.255 ml |
2.51 ml |
50 mM |
0.05 ml |
0.251 ml |
0.502 ml |
|
注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |