TCS 401

99.80%

2-(Oxaloamino)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid hydrochloride

质检下载产品说明书核磁下载 SDS 产品使用指南

品牌：源叶(MedMol)

产品编号：S84609 一键复制产品信息

CAS号：243966-09-8

分子式：C₁₀H₁₁ClN₂O₅S

分子量：306.7227

别名：TCS-401 (HCI), TCS 401 (HCI), TCS401 (HCI), TCS-401 Hydrochloride

货号	规格	价格	上海	北京	珠海	重庆	武汉
S84609-5mg	99.80%	￥140.00 S84609-5mg ￥140.00 现货	7 7	-	-	-	-
S84609-10mg	99.80%	￥240.00 S84609-10mg ￥240.00 现货	3 3	-	-	-	-
S84609-25mg	99.80%	￥550.00 S84609-25mg ￥550.00 现货	3 3	-	-	-	-
S84609-100mg	≥98%	￥1910.00 S84609-100mg ￥1910.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B; Ki = 0.29 μM)

靶点：

Phosphatase

体外研究：

TCS 401 promoted the proliferation and expression of cyclin A and cyclin D1 in RPE cells. TCS 401 induced RPE cells to differentiate toward better contractility and motility. A migration assay proved that inhibiting PTP1B improved the migratory activity of RPE cells. TCS 401 activated extracellular signal-regulated kinase (Erk) and protein kinase B (Akt) phosphorylation. Pretreatment with PD98059 and LY294002 abolished TCS 401-induced activation of Erk, Akt, cell proliferation, and cell migration

细胞实验：

From the cultured RPE cells treated with TCS 401, cell proliferation was assessed using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetracolium bromide assay, and the protein expression levels of cyclin A and cyclin D1 were determined. The effect of TCS 401 on cell differentiation was confirmed by immunostaining for α-smooth muscle actin and by western blot. Cell migration activity and PTP1B signaling mechanism were determined. Migration Assay was used to evaluate cell migration activity. PTP1B signaling mechanism was determined by use of PD98059 and LY294002.

参考文献：

1. Du Z D , Hu L T , Zhao G Q , et al. Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells[J]. Molecular vision, 2015, 21:523-531. 2. Necrotic renal epithelial cell inhibits renal interstitial fibroblast activation: role of protein tyrosine phosphatase 1B.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.26 ml	16.301 ml	32.603 ml
5 mM	0.652 ml	3.26 ml	6.521 ml
10 mM	0.326 ml	1.63 ml	3.26 ml
50 mM	0.065 ml	0.326 ml	0.652 ml