| 产品描述： | Glutaminase C-IN-1 (Compound 968) is an allosteric inhibitor of Glutaminase C that inhibits cancer cell growth without affecting their normal cellular counterparts |
| 靶点： |
Glutaminase C;Glutaminase |
| 体外研究： |
Glutaminase C-IN-1 (Compound 968) (10 μM; 14 d) inhibits cellular transformation in NIH 3T3 cells. Glutaminase C-IN-1 (10 μM; 6 d) blocks the signaling activity of a specific target of Dbl. Glutaminase C-IN-1 blocks the transforming activity of human breast cancer cells. Glutaminase C-IN-1 (10 μM) blocks glutaminolysis in transformed cells. Glutaminase C-IN-1 preferentially binds to the monomeric state of Glutaminase C. Cell Viability Assay Cell Line: MDA-MB231 cells, SKBR3 cells, and NIH 3T3 cells Concentration: 10 μM Incubation Time: 5 h Result: Inhibited cell growth. |
| 体内研究： |
Glutaminase C-IN-1 (Compound 968) (200 μg/mouse; i.p.; daily for 12 days) reduces tumor volume in mice. Animal Model: SCID mice with P493 B lymphoma cells Dosage: 200 μg/mouse Administration: Intraperitoneal injection, daily for 12 days Result: Caused a ~50% reduction in the size of the tumors. |
| 参考文献： |
1. Wang JB, et al. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell. 2010 Sep 14;18(3):207-19. 2. Stalnecker CA, et al. Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):394-9. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.103 ml |
10.517 ml |
21.034 ml |
| 5 mM |
0.421 ml |
2.103 ml |
4.207 ml |
| 10 mM |
0.21 ml |
1.052 ml |
2.103 ml |
| 50 mM |
0.042 ml |
0.21 ml |
0.421 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京