C29 99.73%
| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S85100-1mg促销 |
99.73% | ￥520.00 ￥460.00 |
1 | - | - | - | - |
|
S85100-2mg促销 |
99.73% | ￥800.00 ￥720.00 |
3 | - | - | - | - |
|
S85100-5mg促销 |
99.73% | ￥1440.00 ￥1290.00 |
6 | - | - | - | - |
|
S85100-10mg促销 |
99.73% | ￥1620.00 ￥1450.00 |
5 | - | - | - | - |
|
S85100-25mg促销 |
99.73% | ￥2400.00 ￥2160.00 |
6 | - | - | - | - |
|
S85100-50mg促销 |
99.73% | ￥4200.00 ￥3200.00 |
1 | - | - | - | - |
|
S85100-100mg促销 |
99.73% | ￥5120.00 ￥4600.00 |
2 | 2 | 2 | - | - |
|
| 产品描述： | C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | TLR | ||||||||||||||||||||
| 体外研究： | C29 blunts hTLR2/1 and hTLR2/6 signaling in HEK-TLR2 Stable transfectants and THP-1 Cells. C29 blocks P3C- and P2C-induced IL-8 mRNA dose-dependently in HEK-TLR2 stable transfectants. C29 also inhibits P3C- and P2C-induced IL-1β gene expression significantly at both 1 h and 4 h following stimulation, as well as both P3C- and P2C-induced NF-κB–luciferase activity in transiently transfected HEK293T cells expressing hTLR2 and an NF-κB–sensitive luciferase reporter construct. C29 preferentially inhibits TLR2/1 signaling in primary murine macrophages. C29 blocks TLR2 bacterial agonist-induced proinflammatory gene expression in HEK-TLR2 Cells and murine macrophages. C29 inhibits ligand-induced interaction of TLR2 with MyD88 and blocks MAPK and NF-κB activation | ||||||||||||||||||||
| 体内研究： | C29L inhibits TLR2/1-induced inflammation in mice. Mice treated twice with C29L before administration of P3C significantly blocks IL-12 p40 and TNF-α liver cytokine mRNA and serum protein. C29L has a significant inhibitory effect at the later time point for IL-12 p40 | ||||||||||||||||||||
| 参考文献： | 1. Mistry P, et al. Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5455-60. 2. Du J, Li J, Zhu J, et al. Structural characterization and immunomodulatory activity of a novel polysaccharide from Ficus carica[J]. Food & function. 2018 Jul 17;9(7):3930-3943. 3. Li Y, Niu M, Zhao A, et al. CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson’s disease[J]. Journal of Neuroinflammation. 2019, 16(1): 1-14. 4. Jiang S, Yin H, Qi X, et al. Immunomodulatory effects of fucosylated chondroitin sulfate from Stichopus chloronotus on RAW 264.7 cells[J]. Carbohydrate Polymer. 2020, 251: 117088. 5. Wen Y, Peng D, Li C, et al. A new polysaccharide isolated from Morchella importuna fruiting bodies and its immunoregulatory mechanism[J]. International Journal of Biological Macromolecules. 2019, 137: 8-19. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
参考文献(2篇)
2. [IF=7.7] Jinyan Gu et al."Identification of an arabinogalactan with special structure from Moringa Oleifera Lam. leaf and exploration of its immunomodulatory activity."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2024 Aug;:134616
1. [IF=5.7] Jinyan Gu et al."Highly Branched Rhamnogalacturonan-I Type Pectin from Wolfberry: Purification, Characterization, and Structure-Prebiotic/Immunomodulatory Activity Relationship."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.2024;XXXX(XXX):XXX-XXX
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