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• 产品描述： Clofoctol is a bacteriostatic antibiotic. Clofoctol is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria. Clofoctol is only functional against Gram-positive bacteria and can penetrate into human lung tissue. Clofoctol is also an inhibitor of prostate cancer. Clofoctol has antiviral potency

• 靶点： Bacterial;SARS-CoV;Antibiotic;Antibacterial;Antibiotic

• 体内研究：
  Clofoctol (175 mg/kg; i.p.; daily for 37 days) is capable of blocking tumour growth without apparent toxicity in a mouse model of human prostate cancer xenograft. Clofoctol (62.5 mg/kg; i.p.; twice) inhibits SARS-CoV-2 replication and lowers inflammation in lungs in mice with SARS-CoV-2 infection Animal Model: Male athymic nude mice (BALB/c, nu/nu-NCr) aged 4–6 weeks, human prostate cancer xenograft model Dosage: 175 mg/kg Administration: Intraperitoneal injection, daily for 37 days Result: Significantly inhibited PC3 tumour growth, tumour weight was also reduced by 60%.

• 参考文献：
  1. Ghilardi PL, et al. Treatment of ear, nose and throat infections with clofoctol. Drugs Exp Clin Res. 1985;11(11):815-8. 2. Wang M, et al. Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer. Br J Pharmacol. 2014 Oct;171(19):4478-89. 3. Belouzard S, et al. Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice. PLoS Pathog. 2022 May 19;18(5):e1010498.

• 溶解性： Soluble  in  DMSO

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.737 ml	13.686 ml	27.372 ml
  5 mM	0.547 ml	2.737 ml	5.474 ml
  10 mM	0.274 ml	1.369 ml	2.737 ml
  50 mM	0.055 ml	0.274 ml	0.547 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *